Evidence map›Paper›PMID 27960308›Full record

ArticleJournal of the American Chemical Society2016

Chemical Synthesis and Self-Assembly of a Ladderane Phospholipid.

Jaron A M Mercer, Carolyn M Cohen, Steven R Shuken, Anna M Wagner, Myles W Smith, Frank R Moss, Matthew D Smith, Riku Vahala, Alejandro Gonzalez-Martinez, Steven G Boxer and 1 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Homologous Ladder Cyclohexasilanes.Angewandte Chemie (International ed. in English) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Anammox BacterialInternational journal of molecular sciences · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Photosensitized [2+2]-Cycloadditions of Alkenylboronates and Alkenes.Angewandte Chemie (International ed. in English) · 2022
    Article
  16. Article
  17. Article
  18. Ladderane Natural Products: From the Ground Up.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jaron A M MercerDepartment of Chemistry, Stanford University , Stanford, California 94305, United States.
Carolyn M CohenDepartment of Chemistry, Stanford University , Stanford, California 94305, United States.
Steven R ShukenDepartment of Chemistry, Stanford University , Stanford, California 94305, United States.
Anna M WagnerDepartment of Chemistry, Stanford University , Stanford, California 94305, United States.
Myles W SmithDepartment of Chemistry, Stanford University , Stanford, California 94305, United States.
Frank R MossDepartment of Chemistry, Stanford University , Stanford, California 94305, United States.
Matthew D SmithDepartment of Chemistry, Stanford University , Stanford, California 94305, United States.
Riku VahalaDepartment of Built Environment, School of Engineering, Aalto University, Aalto , FI-00076 Espoo, Finland.
Alejandro Gonzalez-MartinezDepartment of Built Environment, School of Engineering, Aalto University, Aalto , FI-00076 Espoo, Finland.
Steven G BoxerDepartment of Chemistry, Stanford University , Stanford, California 94305, United States.
Noah Z BurnsDepartment of Chemistry, Stanford University , Stanford, California 94305, United States.

Funding

Biophysical Studies of Macromolecules and Molecular AssembliesR35GM118044 · NIGMS · STANFORD UNIVERSITY · PI STEVEN G. BOXER · 2016 to 2026
$7.2M
Membrane Fusion, Organization, and Dynamics Using Supported BilayersR01GM069630 · NIGMS · STANFORD UNIVERSITY · PI BOXER, STEVEN G. · 2004 to 2015
$3.8M
NIGMS NIH HHS R01 GM069630NIGMS NIH HHS R35 GM118044
6 · The paper itself

Abstract

Ladderane lipids produced by anammox bacteria constitute some of the most structurally fascinating yet poorly studied molecules among biological membrane lipids. Slow growth of the producing organism and the inherent difficulty of purifying complex lipid mixtures have prohibited isolation of useful amounts of natural ladderane lipids. We have devised a highly selective total synthesis of ladderane lipid tails and a full phosphatidylcholine to enable biophysical studies on chemically homogeneous samples of these molecules. Additionally, we report the first proof of absolute configuration of a natural ladderane.

Indexed as

Molecular ConformationPhospholipidsPhospholipids

Identifiers

PMID27960308
PMCPMC5279923

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.