Evidence map›Paper›PMID 27960107›Full record

ArticleNeurobiology of aging2017

Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.

Neelam Shahani, Wen-Chin Huang, Megan Varnum, Damon T Page, Srinivasa Subramaniam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. iScience · 2022
    Article
  3. Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Neelam ShahaniDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL, USA.
Wen-Chin HuangDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL, USA.
Megan VarnumDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL, USA.
Damon T PageDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL, USA.
Srinivasa SubramaniamDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL, USA. Electronic address: ssubrama@scripps.edu.
Scripps Research Institute · US

Funding

Impact of Pten mutations on brain growth and social behavioral development.R01MH105610 · NIMH · SCRIPPS FLORIDA · PI PAGE, DAMON THERON · 2015 to 2019
$2.4M
mTOR Signaling in Striatum: Regulation and FunctionR01NS087019 · NINDS · SCRIPPS FLORIDA · PI SUBRAMANIAM, SRINI · 2015 to 2019
$2.3M
Rhes-SUMO circuitry in Huntington's Disease PathogenesisR01NS094577 · NINDS · SCRIPPS FLORIDA · PI SUBRAMANIAM, SRINI · 2016 to 2019
$1.7M
NIMH NIH HHS R01 MH105610NINDS NIH HHS R01 NS087019NINDS NIH HHS R01 NS094577
6 · The paper itself

Abstract

The precise molecular and cellular events responsible for age-dependent cognitive dysfunctions remain unclear. We report that Rheb (ras homolog enriched in brain) GTPase, an activator of mammalian target of rapamycin (mTOR), regulates memory functions in mice. Conditional depletion of Rheb selectively in the forebrain of mice obtained from crossing Rheb

Indexed as

AgingAlzheimer DiseaseAmyloid Precursor Protein SecretasesAnimalsAspartic Acid EndopeptidasesCognitive DysfunctionMemory DisordersMice, Mutant StrainsMice, TransgenicMolecular Targeted TherapyMonomeric GTP-Binding ProteinsNeuropeptidesProsencephalonRas Homolog Enriched in Brain ProteinSirolimusSpatial MemoryAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBace1 protein, mouseMonomeric GTP-Binding ProteinsNeuropeptidesRas Homolog Enriched in Brain ProteinRheb protein, mouseSirolimusAlzheimer's diseaseBACE1ForebrainRhebSpatial memory

Identifiers

PMID27960107
PMCPMC5209246
OpenAlexW2549296111

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.