ArticleCancer cell2016
Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.
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In one paragraph
Article in Cancer cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 1 of them a synthesis that pooled it.
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0cells of the map it votes in
151citing papers in PubMed, 1 pooled it
–field-weighted citation impact
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Who cites it
151 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular subgrouping of atypical teratoid/rhabdoid tumors-a reinvestigation and current consensus.Neuro-oncology · 2020Pooled it
- Phase 3 randomized trial of high-dose methotrexate for young children with high-risk embryonal brain tumors: A report from the Children's Oncology Group.Neuro-oncology · 2025Trial
- Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials.Acta neuropathologica · 2020Trial
- A Phase Ib Case Series Using Bortezomib With Chemotherapy in Atypical Teratoid/Rhabdoid Tumors.Cancer medicine · 2026Article
- Paediatric Therapeutic Development Workshop on rhabdoid tumours.British journal of cancer · 2026Review
- The future of targeted therapies for pediatric central nervous system tumors.Neuro-oncology advances · 2026Review
- Pediatric Spinal Atypical Teratoid Rhabdoid Tumor: Recent Advances in Biology and Management Options.Cancers · 2026Review
- A PDGFRB-CD44-MIF crosstalk promotes cancer-associated cellular phenotypes in ATRT-TYR/MYC cell lines.Frontiers in oncology · 2026Article
- Overcoming immunotherapy barriers in pediatric brain tumors: epigenetic strategies.Frontiers in oncology · 2026Review
- Histogenesis of Atypical Teratoid Rhabdoid Tumors: Anatomical and Embryological Perspectives.Cancers · 2025Article
- Disordered DNA methylation leads to targetable transcriptional plasticity in ATRT.Acta neuropathologica communications · 2025Article
- A cycling, progenitor-like cell population at the base of atypical teratoid rhabdoid tumor subtype differentiation trajectories.Neuro-oncology · 2025Article
- Atypical Teratoid Rhabdoid Tumor: How Tumor Diagnostic Methods in the Laboratory Have Evolved over the Past 40 Years.Cancers · 2025Article
- Epigenetic reprogramming as the nexus of cancer stemness and therapy resistance: implications for biomarker discovery.Discover oncology · 2025Review
- SWI/SNF complexes govern ontology-specific transcription factor function in MYC-subtype atypical teratoid rhabdoid tumor.Neuro-oncology · 2025Article
- Clinical and Molecular Characteristics of 100 Atypical Teratoid Rhabdoid Tumor Patients from Low- and Middle-Income Countries.Cancers · 2025Article
- Spatial and multi-omic profiling reveals genes and pathways associated with cytotoxic lymphocyte infiltration in malignant rhabdoid tumor.Research square · 2025Article
- SMARCB1-related schwannomatosis and other SMARCB1-associated phenotypes: clinical spectrum and molecular pathogenesis.Familial cancer · 2025Review
- SIRT2 Regulates the SMARCB1 Loss-Driven Differentiation Block in ATRT.Molecular cancer research : MCR · 2025Article
- Image-guided targeting of mitochondrial metabolism sensitizes pediatric malignant rhabdoid tumors to low-dose radiotherapy.Science advances · 2025Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
118 authors.
Jonathon TorchiaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Brian GolbournDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Shengrui FengDepartment of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
King Ching HoDivision of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Patrick Sin-ChanDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Alexandre VasiljevicDepartment of Pathology, Groupement Hospitalier Est, CHU de Lyon, Lyon-Bron 69677, France.
Joseph D NormanDivision of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Paul GuilhamonPrincess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
Livia GarziaProgram in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Natalia R AgamezDivision of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Mei LuDivision of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Tiffany S ChanDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Daniel PicardDivision of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Pasqualino de AntonellisProgram in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Dong-Anh Khuong-QuangDepartment of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada; Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada.
Aline C PlanelloPrincess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
Constanze ZellerPrincess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
Dalia Barsyte-LovejoyPrincess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
Lucie Lafay-CousinDivision of Pediatric Hematology/Oncology, Alberta Children's Hospital, AB T3B6A8, Canada.
Louis LetourneauGenome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada.
Mathieu BourgeyGenome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada.
Man YuArthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Deena M A GendooDivision of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Misko DzambaDepartment of Computer Science, University of Toronto, Toronto, ON M5G0A4, Canada.
Mark BarszczykArthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Tiago MedinaPrincess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
Alexandra N RiemenschneiderDivision of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
A Sorana MorrissyProgram in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Young-Shin RaDepartment of Neurosurgery, Asan Medical Center, Seoul 138-736, Korea.
Vijay RamaswamyDivision of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Marc RemkeDivision of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Christopher P DunhamDivision of Anatomic Pathology, Children's and Women's Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada.
Stephen YipDepartment of Pathology & Laboratory Medicine, University of British Columbia, V6T1Z3, Canada.
Ho-Keung NgDepartment of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China.
Jian-Qiang LuLaboratory Medicine and Pathology, Stollery Children's Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada.
Vivek MehtaDivision of Neurosurgery, Stollery Children's Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada.
Steffen AlbrechtDepartment of Pathology, McGill University, Montreal, QC H3Z2Z3, Canada.
Jose PimentelDivison of Pathology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal.
Jennifer A ChanDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N1N4, Canada.
Gino R SomersDepartment of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Claudia C FariaDepartment of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal.
Lucia RoqueCytometry and Cytogenetic Laboratory, CIPM, Portuguese Cancer Institute, Lisbon 1099-023, Portugal.
Maryam FouladiDivision of Oncology, Department of Cancer and Blood Diseases, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.
Lindsey M HoffmanDepartment of Pediatrics, University of Colorado, Denver, CO 80045, USA.
Andrew S MooreOncology Service, Children's Health Queensland Hospital; University of Queensland Diamantina Institute, Brisbane, QLD 4102, Australia.
Yin WangResearch Institute of Health Development Strategies, Fudan University, Shanghai 200032, China.
Seung Ah ChoiDivision of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 03080, Korea.
Jordan R HansfordRoyal Children's Hospital, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia.
Daniel CatchpooleChildren's Cancer Research Unit, Children's Hospital at Westmead, Westmead, NSW 2145, Australia.
Diane K BirksDepartment of Pediatrics, University of Colorado, Denver, CO 80045, USA.
Nicholas K ForemanDepartment of Pediatrics, University of Colorado, Denver, CO 80045, USA.
Doug StrotherDivision of Pediatric Hematology/Oncology, Stollery Children's Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada.
Almos KleknerDepartment of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary.
Laszló BognárDepartment of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary.
Miklós GaramiSecond Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary.
Péter HauserSecond Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary.
Tibor HortobágyiDepartment of Histopathology, University of Szeged, Szeged 6720, Hungary.
Beverly WilsonDivision of Pediatric Hematology/Oncology, Stollery Children's Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada.
Juliette HukinDivision of Hematology and Oncology, Children's and Women's Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada.
Anne-Sophie CarretDepartment of Pediatrics, Division of Hematology-Oncology, Université de Montréal/CHU Sainte-Justine, Montreal, QC H3T1C5, Canada.
Timothy E Van MeterDepartment of Neurosurgery, Virginia Commonwealth University, Richmond, VA 23298-0631, USA.
Eugene I HwangDepartment of Oncology, Children's National Medical Center, Washington, DC 20010, USA.
Amar GajjarDivision of Neuro-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Shih-Hwa ChiouDepartment of Medical Research, Taipei Veterans General Hospital and National Yang-Ming University, Taipei 112, Taiwan.
Hideo NakamuraDepartment of Neurosurgery, Kumamoto University, Kumamoto 860-8556, Japan.
Helen ToledanoDepartment of Pediatric Hematology Oncology, Children's Medical Center of Israel, Petach Tikva 49202, Isreal.
Iris FriedDepartment of Pediatric Hematology-Oncology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel.
Daniel FultsDepartment of Neurosurgery, University of Utah, School of Medicine, Salt Lake City, UT 84132, USA.
Takafumi WatayaDepartment of Neurosurgery, Shizuoka Children's Hospital, Shizuoka 420-8660, Japan.
Chris FryerDivision of Hematology and Oncology, Children's and Women's Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada.
David D EisenstatDivision of Pediatric Hematology/Oncology, Stollery Children's Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada.
Katrin ScheinemannDepartment of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada.
Adam J FlemingDepartment of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada.
Donna L JohnstonDepartment of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada.
Jean MichaudPathology and Laboratory Medicine, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada.
Shayna ZelcerDivision of Pediatric Hematology/Oncology, Children's Hospital, London Health Sciences Center, London, ON N6A5A5, Canada.
Robert HammondDepartment of Pathology and Laboratory Medicine, Children's Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada.
Samina AfzalDepartment of Pediatrics, Dalhousie University, Halifax, NS B3H4R2, Canada.
David A RamsayDepartment of Pathology and Laboratory Medicine, Children's Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada.
Nongnuch SirachainanDepartment of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand.
Suradej HongengDepartment of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand.
Noppadol LarbcharoensubDepartment of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Richard G GrundyChildren's Brain Tumour Research Centre, University of Nottingham, Nottingham NG72RD, England.
Rishi R LullaDivision of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.
Jason R FangusaroDivision of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.
Harriet DrukerDivision of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Ute BartelsDivision of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Ronald GrantDivision of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
David MalkinDepartment of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
C Jane McGladeDepartment of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Theodore NicolaidesDepartment of Pediatrics (Hematology/Oncology), University of California, San Francisco, San Francisco, CA 94143-0112, USA.
Tarik TihanDepartment of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA.
Joanna PhillipsDepartment of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA.
Jacek MajewskiDepartment of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada; Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada.
Alexandre MontpetitGenome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada.
Guillaume BourqueDepartment of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada; Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada.
Gary D BaderDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5G0A4, Canada.
Alyssa T ReddyDepartment of Pediatric Hematology and Oncology, University of Alabama, Birmingham, AL 35233, USA.
G Yancey GillespieDepartment of Neurosurgery, University of Alabama, Birmingham, AL 35233, USA.
Monika Warmuth-MetzDepartment of Neuroradiology, University of Würzburg, Würzburg 97070, Germany.
Stefan RutkowskiDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
Uri TaboriDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Mathieu LupienDepartment of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
Michael BrudnoDepartment of Computer Science, University of Toronto, Toronto, ON M5G0A4, Canada; Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Ulrich SchüllerDepartment of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
Torsten PietschInstitute for Neuropathology, University of Bonn Medical Center, Bonn 53105, Germany.
Alexander R JudkinsDepartment of Pathology & Laboratory Medicine, Children's Hospital of Los Angeles, Los Angeles, CA 90027, USA.
Cynthia E HawkinsDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Pathology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Eric BouffetDivision of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Seung-Ki KimDivision of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 03080, Korea.
Peter B DirksDivision of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Michael D TaylorDivision of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Anat Erdreich-EpsteinDepartment of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Cheryl H ArrowsmithPrincess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
Daniel D De CarvalhoDepartment of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada. Electronic address: ddecarv@uhnresearch.ca.
James T RutkaDepartment of Surgery, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address: james.rutka@sickkids.ca.
Nada JabadoDepartment of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada; Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada. Electronic address: nada.jabado@mcgill.ca.
Annie HuangDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address: annie.huang@sickkids.ca.
Funding
TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3MCytoscape: A Modeling Platform for Biomolecular NetworksR01GM070743 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2004 to 2016
$5.7MPathway Commons: Research Resource for Biological PathwaysP41HG004118 · NHGRI · SLOAN-KETTERING INST CAN RESEARCH · PI SANDER, CHRIS · 2008 to 2011
$3.8MCytoscape: A Modeling Platform for Biomolecular NetworksR01HG009979 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2017 to 2021
$3.5MNHGRI NIH HHS P41 HG004118NHGRI NIH HHS R01 HG009979NIGMS NIH HHS P41 GM103504NIGMS NIH HHS R01 GM070743
Abstract
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.
Indexed as
Cell Line, TumorCell ProliferationCell SurvivalCentral Nervous System NeoplasmsChromatinDasatinibDNA MethylationEpigenesis, GeneticEpigenomicsHumansMutationProtein Kinase InhibitorsPyrimidinesReceptor, Platelet-Derived Growth Factor betaRhabdoid TumorSMARCB1 ProteinChromatinDasatinibnilotinibPDGFRB protein, humanProtein Kinase InhibitorsPyrimidinesReceptor, Platelet-Derived Growth Factor betaSMARCB1 ProteinSMARCB1 protein, humanATRTenhancerepigenomicsgenomicsrhabdoid tumorssubgroup-specific therapeutics
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