ArticlePloS one2016
Alternative Splicing of Barley Clock Genes in Response to Low Temperature.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Light-Dependent Temporal Reprogramming of Alternative Splicing Dynamics Under Salt Stress in Sweet Potato (Plants (Basel, Switzerland) · 2026Article
- Molecular genetic examination of Circadian Clock Associated 1 gene (CCA1) in hexaploid wheat.BMC plant biology · 2026Article
- Integrating temperature into the Arabidopsis circadian system.Npj biological timing and sleep · 2025Review
- Unlocking allelic variation in circadian clock genes to develop environmentally robust and productive crops.Planta · 2024Review
- Importance of pre-mRNA splicing and its study tools in plants.Advanced biotechnology · 2024Review
- Alternative Splicing Variation: Accessing and Exploiting in Crop Improvement Programs.International journal of molecular sciences · 2023Review
- BaRTv2: a highly resolved barley reference transcriptome for accurate transcript-specific RNA-seq quantification.The Plant journal : for cell and molecular biology · 2022Article
- The Roles of Temperature-Related Post-Transcriptional Regulation in Cereal Floral Development.Plants (Basel, Switzerland) · 2021Review
- Reading between the Lines: RNA-seq Data Mining Reveals the Alternative Message of the Rice Leaf Transcriptome in Response to Heat Stress.Plants (Basel, Switzerland) · 2021Article
- EORNA, a barley gene and transcript abundance database.Scientific data · 2021Article
- Temperature-Dependent Alternative Splicing of Precursor mRNAs and Its Biological Significance: A Review Focused on Post-Transcriptional Regulation of a Cold Shock Protein Gene in Hibernating Mammals.International journal of molecular sciences · 2020Review
- BaRTv1.0: an improved barley reference transcript dataset to determine accurate changes in the barley transcriptome using RNA-seq.BMC genomics · 2019Article
- Genome-wide association mapping in a diverse spring barley collection reveals the presence of QTL hotspots and candidate genes for root and shoot architecture traits at seedling stage.BMC plant biology · 2019Article
- Alternative Splicing of Circadian Clock Genes Correlates With Temperature in Field-Grown Sugarcane.Frontiers in plant science · 2019Article
- Cold-Dependent Expression and Alternative Splicing of Arabidopsis Long Non-coding RNAs.Frontiers in plant science · 2019Article
- Circadian Regulation of the Plant Transcriptome Under Natural Conditions.Frontiers in genetics · 2019Review
- How does temperature affect splicing events? Isoform switching of splicing factors regulates splicing of LATE ELONGATED HYPOCOTYL (LHY).Plant, cell & environment · 2018Article
- Global spatial analysis of Arabidopsis natural variants implicates 5'UTR splicing of LATE ELONGATED HYPOCOTYL in responses to temperature.Plant, cell & environment · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Alternative splicing (AS) is a regulated mechanism that generates multiple transcripts from individual genes. It is widespread in eukaryotic genomes and provides an effective way to control gene expression. At low temperatures, AS regulates Arabidopsis clock genes through dynamic changes in the levels of productive mRNAs. We examined AS in barley clock genes to assess whether temperature-dependent AS responses also occur in a monocotyledonous crop species. We identify changes in AS of various barley core clock genes including the barley orthologues of Arabidopsis AtLHY and AtPRR7 which showed the most pronounced AS changes in response to low temperature. The AS events modulate the levels of functional and translatable mRNAs, and potentially protein levels, upon transition to cold. There is some conservation of AS events and/or splicing behaviour of clock genes between Arabidopsis and barley. In addition, novel temperature-dependent AS of the core clock gene HvPPD-H1 (a major determinant of photoperiod response and AtPRR7 orthologue) is conserved in monocots. HvPPD-H1 showed a rapid, temperature-sensitive isoform switch which resulted in changes in abundance of AS variants encoding different protein isoforms. This novel layer of low temperature control of clock gene expression, observed in two very different species, will help our understanding of plant adaptation to different environments and ultimately offer a new range of targets for plant improvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.