ArticlePloS one2016
Former Very Preterm Infants Show an Unfavorable Cardiovascular Risk Profile at a Preschool Age.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Triglyceride profiles in preterm infants reveal dynamic and age-specific trajectories.Frontiers in pediatrics · 2026Article
- Young hearts, early risks: novel cardiovascular biomarkers in former very preterm infants at kindergarten age.Pediatric research · 2024Article
- Cardiac biomarkers and left ventricular systolic function in former very preterm infants and term controls at preschool age.Frontiers in pediatrics · 2024Article
- Cardiovascular health profiles in adolescents being born term or preterm-results from the EVA-Tyrol study.BMC cardiovascular disorders · 2023Article
- Impact of very preterm birth and post-discharge growth on cardiometabolic outcomes at school age: a retrospective cohort study.BMC pediatrics · 2021Article
- Citrulline, Biomarker of Enterocyte Functional Mass and Dietary Supplement. Metabolism, Transport, and Current Evidence for Clinical Use.Nutrients · 2021Review
- Article
- Postnatal Expression Profile of MicroRNAs Associated with Cardiovascular Diseases in 3- to 11-Year-Old Preterm-Born Children.Biomedicines · 2021Article
- Racial differences of early vascular aging in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2021Review
- Very preterm birth results in later lower platelet activation markers.Pediatric research · 2021Observational
- Impact of size at birth and postnatal growth on metabolic and neurocognitive outcomes in prematurely born school-age children.Scientific reports · 2021Article
- Adrenal Steroid Metabolism and Blood Pressure in 5- to 7-Year-Old Children Born Preterm as Compared to Peers Born at Term.Frontiers in pediatrics · 2021Article
- Comprehensive men's health and male infertility.Translational andrology and urology · 2020Review
- The Tyrolean early vascular ageing-study (EVA-Tyrol): study protocol for a non-randomized controlled trial : Effect of a cardiovascular health promotion program in youth, a prospective cohort study.BMC cardiovascular disorders · 2020Article
- Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children.Frontiers in pediatrics · 2020Article
- Apolipoprotein Profiles in Very Preterm and Term-Born Preschool Children.Journal of the American Heart Association · 2019Article
- Birth Intervals and Health in Adulthood: A Comparison of Siblings Using Swedish Register Data.Demography · 2018Article
- Former Very Preterm Infants Show Alterations in Thyroid Function at a Preschool Age.BioMed research international · 2017Article
- Prevalence of diabetes and obesity in association with prematurity and growth restriction.Diabetes, metabolic syndrome and obesity : targets and therapy · 2017Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease is the leading cause of death worldwide. Evidence points towards an unfavorable cardiovascular risk profile of former preterm infants in adolescence and adulthood. The aim of this study was to determine whether cardiovascular risk predictors are detectable in former very preterm infants at a preschool age. Five- to seven-year-old children born at <32 weeks' gestational age were included in the study. Same-aged children born at term served as controls. Basic data of study participants were collected by means of follow-up databases and standardized questionnaires. At study visit, anthropometric data, blood pressure readings and aortic intima-media thickness were assessed. Blood samples were obtained after an overnight fast. In comparison to children born at term, former preterm infants had higher systolic and diastolic blood pressure readings (odds ratio [95% confidence interval] per 1-SD higher blood pressure level 3.2 [2.0-5.0], p<0.001 and 1.6 [1.1-1.2], p = 0.008), fasting glucose levels (OR [95% CI] 5.2 [2.7-10.1], p<0.001), homeostasis model assessment index (OR [95% CI] 1.6 [1.0-2.6], p = 0.036), and cholesterol levels (OR [95% CI] 2.1 [1.3-3.4], p = 0.002). Systolic prehypertension (23.7% vs. 2.2%; OR [95% CI] 13.8 [3.1-60.9], p = 0.001), elevated glucose levels (28.6% vs. 5.9%; OR [95% CI] 6.4 [1.4-28.8], p = 0.016), and hypercholesterolemia (77.4% vs. 52.9%; OR [95% CI] 3.0 [1.3-7.1], p = 0.010) were significantly more prevalent in the preterm group. As former very preterm infants display an unfavorable cardiovascular risk profile already at a preschool age, implementation of routine cardiovascular follow-up programs might be warranted.
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