Evidence map›Paper›PMID 27959567›Full record

ArticleOrganic letters2017

Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks.

Narendran G-Dayanandan, Eric W Scocchera, Santosh Keshipeddy, Heather F Jones, Amy C Anderson, Dennis L Wright

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Narendran G-DayanandanDepartment of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.ORCID 0000-0002-8922-4339
Eric W ScoccheraDepartment of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.
Santosh KeshipeddyDepartment of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.
Heather F JonesDepartment of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.
Amy C AndersonDepartment of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.
Dennis L WrightDepartment of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06269, United States.ORCID 0000-0003-4634-3351

Funding

Propargyl-linked Antifolates Targeting Klebsiella pneumoniaeR01AI104841 · NIAID · UNIVERSITY OF CONNECTICUT STORRS · PI WRIGHT, DENNIS L. · 2014 to 2018
$3.1M
Antimetabolites Effective against Resistant Gram-positive BacteriaR01AI111957 · NIAID · UNIVERSITY OF CONNECTICUT STORRS · PI WRIGHT, DENNIS L. · 2014 to 2017
$2.2M
NIAID NIH HHS R01 AI104841NIAID NIH HHS R01 AI111957
6 · The paper itself

Abstract

To develop next generation antifolates for the treatment of trimethoprim-resistant bacteria, synthetic methods were needed to prepare a diverse array of 3-aryl-propynes with various substitutions at the propargyl position. A direct route was sought whereby nucleophilic addition of acetylene to aryl carboxaldehydes would be followed by reduction or substitution of the resulting propargyl alcohol. The direct reduction, methylation, and dimethylation of these readily available alcohols provide efficient access to this uncommon functional array. In addition, an unusual silane exchange reaction was observed in the reduction of the propargylic alcohols.

Indexed as

AlcoholsAldehydesAlkynesAnti-Bacterial AgentsDrug DesignDrug Resistance, BacterialFolic Acid AntagonistsHumansMethylationMolecular StructureOxidation-ReductionStereoisomerismStructure-Activity RelationshipTrimethoprimAlcoholsAldehydesAlkynesAnti-Bacterial AgentsFolic Acid AntagonistsTrimethoprim

Identifiers

PMID27959567
PMCPMC5253071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.