Evidence map›Paper›PMID 27959338›Full record

ArticleScientific reports2016

Analysis of complete genomes of the rubella virus genotypes 1E and 2B which circulated in China, 2000-2013.

Zhen Zhu, Min-Hsin Chen, Emily Abernathy, Joseph Icenogle, Shujie Zhou, Changyin Wang, Chunfang Zhao, Yan Wang, Haiyun Chen, Yuan Si and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
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  3. Review
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  7. Cytosine drives evolution of SARS-CoV-2.Environmental microbiology · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhen ZhuWHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Beijing, People's Republic of China.
Min-Hsin ChenMeasles, Mumps, Rubella, and Herpesviruses Laboratory Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Emily AbernathyMeasles, Mumps, Rubella, and Herpesviruses Laboratory Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Joseph IcenogleMeasles, Mumps, Rubella, and Herpesviruses Laboratory Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Shujie ZhouAnhui Center for Disease Control and Prevention, Hefei, People's Republic of China.
Changyin WangShandong Center for Disease Control and Prevention, Jinan, People's Republic of China.
Chunfang ZhaoChongqing Center for Disease Control and Prevention, Chongqing, People's Republic of China.
Yan WangLiaoning Center for Disease Control and Prevention, Changchun, People's Republic of China.
Haiyun ChenHainan Center for Disease Control and Prevention, Haikou, People's Republic of China.
Yuan SiShaanxi Center for Disease Control and Prevention, Xi'an, People's Republic of China.
Wenbo XuWHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Beijing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rubella viruses of genotypes 1E and 2B are currently the most frequently detected wild-type viruses in the world. Genotype 1E viruses from China have been genetically distinct from genotype 1E viruses found elsewhere, while genotype 2B viruses found in China are not distinguishable from genotype 2B viruses from other areas. Genetic clusters of viruses of both genotypes were defined previously using sequences of the 739-nt genotyping window. Here we report phylogenic analysis using whole genomic sequences from seven genotype 1E and three genotype 2B viruses which were isolated in China between 2000 and 2013 and confirm the subgrouping of current circulating genotypes 1E and 2B viruses. In addition, the whole genomic characterization of Chinese rubella viruses was clarified. The results indicated that the Chinese rubella viruses were highly conserved at the genomic level, and no predicted amino acid variations were found at positions where functional domains of the proteins were identified. Therefore, it gives us the idea that the rubella control and elimination goal should be achieved if vaccine immunization coverage continues maintaining at the high level.

Indexed as

GenotypeChinaFemaleGenome, ViralGenotyping TechniquesHumansMaleRubellaRubella virus

Identifiers

PMID27959338
PMCPMC5154293

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.