ArticleTranslational psychiatry2016
Peripheral blood gene expression profiles linked to monoamine metabolite levels in cerebrospinal fluid.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Peripheral lncRNA-IL1RAP Dysregulation in Schizophrenia: A Multi-Omics Bridge Between Immunity and Diagnosis.Brain and behavior · 2026Article
- Effect of Chronic Stress on Whole Blood Transcriptome: A Meta-Analysis of Publicly Available Datasets from Rodent Models.bioRxiv : the preprint server for biology · 2025Article
- Candidate Genes and Gene Networks Change with Age in Japanese Black Cattle by Blood Transcriptome Analysis.Genes · 2023Article
- RNA biomarkers for alcohol use disorder.Frontiers in molecular neuroscience · 2022Review
- Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model.Frontiers in systems neuroscience · 2021Article
- Longitudinal profiling of the blood transcriptome in an African green monkey aging model.Aging · 2020Article
- Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- Identification of two novel biomarkers of rectal carcinoma progression and prognosis via co-expression network analysis.Oncotarget · 2017Article
- A Single Dose of LSD Does Not Alter Gene Expression of the Serotonin 2A Receptor Gene (Frontiers in pharmacology · 2017Article
- Exploratory Analysis of Sleep Deprivation Effects on Gene Expression and Regional Brain Metabolism.Complex psychiatryArticle
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
Abstract
The blood-brain barrier separates circulating blood from the central nervous system (CNS). The scope of this barrier is not fully understood which limits our ability to relate biological measurements from peripheral to central phenotypes. For example, it is unknown to what extent gene expression levels in peripheral blood are reflective of CNS metabolism. In this study, we examine links between central monoamine metabolite levels and whole-blood gene expression to better understand the connection between peripheral systems and the CNS. To that end, we correlated the prime monoamine metabolites in cerebrospinal fluid (CSF) with whole-genome gene expression microarray data from blood (N=240 human subjects). We additionally applied gene-enrichment analysis and weighted gene co-expression network analyses (WGCNA) to identify modules of co-expressed genes in blood that may be involved with monoamine metabolite levels in CSF. Transcript levels of two genes were significantly associated with CSF serotonin metabolite levels after Bonferroni correction for multiple testing: THAP7 (P=2.8 × 10
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Registered trials
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