ArticleTranslational psychiatry2016
Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.Molecular psychiatry · 2019Pooled it
- Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.Nature genetics · 2018Pooled it
- Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.Nature communications · 2018Pooled it
- Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study.Molecular neurobiology · 2020Trial
- When can whole-genome SNP heritability be reliably estimated from summary statistics?bioRxiv : the preprint server for biology · 2026Article
- Shared genetic influences between blood analyte levels and risk of severe COVID-19.Cell reports · 2022Article
- Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits.Nature communications · 2022Article
- Markers of kidney function, genetic variation related to cognitive function, and cognitive performance in the UK Biobank.BMC nephrology · 2022Article
- Disentangling Independent and Mediated Causal Relationships Between Blood Metabolites, Cognitive Factors, and Alzheimer's Disease.Biological psychiatry global open science · 2022Article
- Consequences of exposure to pollutants on respiratory health: From genetic correlations to causal relationships.PloS one · 2022Article
- Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Cognitive Genomics: Recent Advances and Current Challenges.Current psychiatry reports · 2020Review
- Article
- Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income.Nature communications · 2019Article
- A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome.Nature communications · 2019Article
- Genomic updates in understanding PTSD.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
- Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia.Frontiers in genetics · 2019Article
- Age and cognitive decline in the UK Biobank.PloS one · 2019Article
- Genomic analysis of family data reveals additional genetic effects on intelligence and personality.Molecular psychiatry · 2018Article
- Resting-State Connectivity and Its Association With Cognitive Performance, Educational Attainment, and Household Income in the UK Biobank.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Differences in general cognitive function have been shown to be partly heritable and to show genetic correlations with several psychiatric and physical disease states. However, to date, few single-nucleotide polymorphisms (SNPs) have demonstrated genome-wide significance, hampering efforts aimed at determining which genetic variants are most important for cognitive function and which regions drive the genetic associations between cognitive function and disease states. Here, we combine multiple large genome-wide association study (GWAS) data sets, from the CHARGE cognitive consortium (n=53 949) and UK Biobank (n=36 035), to partition the genome into 52 functional annotations and an additional 10 annotations describing tissue-specific histone marks. Using stratified linkage disequilibrium score regression we show that, in two measures of cognitive function, SNPs associated with cognitive function cluster in regions of the genome that are under evolutionary negative selective pressure. These conserved regions contained ~2.6% of the SNPs from each GWAS but accounted for ~40% of the SNP-based heritability. The results suggest that the search for causal variants associated with cognitive function, and those variants that exert a pleiotropic effect between cognitive function and health, will be facilitated by examining these enriched regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.