ArticleMedical hypotheses2016
Doubt and the decision-making process in obsessive-compulsive disorder.
Article in Medical hypotheses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping the Causal Correlates of Risky and Ambiguous Decision-Making: Evidence from tES Research.Brain topography · 2025Pooled it
- OCD Compulsions as Aberrant Integration of Uncertainty from Local Goals to Global Goals.Computational psychiatry (Cambridge, Mass.) · 2026Article
- Cognitive inflexibility, obsessive-compulsive symptoms and traits and poor post-pandemic adjustment.Neuroscience applied · 2024Review
- Microbial Reprogramming in Obsessive-Compulsive Disorders: A Review of Gut-Brain Communication and Emerging Evidence.International journal of molecular sciences · 2023Review
- Phenomenological Considerations of the World of the Obsessive Patient.Journal of clinical medicine · 2023Article
- Symptom Dimension Breakpoints for the Obsessive-Compulsive Inventory-Child Version (OCI-CV).Child psychiatry and human development · 2023Article
- Metacognition and the effect of incentive motivation in two compulsive disorders: Gambling disorder and obsessive-compulsive disorder.Psychiatry and clinical neurosciences · 2022Article
- Inverse Association Between Resting-State Putamen Activity and Iowa Gambling Task Performance in Patients With Obsessive-Compulsive Disorder and Control Subjects.Frontiers in psychiatry · 2022Article
- Accumulation of evidence during decision making in OCD patients.Frontiers in psychiatry · 2022Article
- Obsessive-Compulsive Disorder and Decision Making under Ambiguity: A Systematic Review with Meta-Analysis.Brain sciences · 2021Article
- OCD Influences Evidence Accumulation During Decision Making in Males but Not Females During Perceptual and Value-Driven Choice.Frontiers in psychiatry · 2021Article
- The Centrality of Doubting and Checking in the Network Structure of Obsessive-Compulsive Symptom Dimensions in Youth.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Article
- Sub-graph entropy based network approaches for classifying adolescent obsessive-compulsive disorder from resting-state functional MRI.NeuroImage. Clinical · 2020Article
- Validating a dimension of doubt in decision-making: A proposed endophenotype for obsessive-compulsive disorder.PloS one · 2019Article
- Level of Insight in Patients With Obsessive-Compulsive Disorder: An Exploratory Comparative Study Between Patients With "Good Insight" and "Poor Insight".Frontiers in psychiatry · 2019Article
- Psychiatric Symptom Dimensions Are Associated With Dissociable Shifts in Metacognition but Not Task Performance.Biological psychiatry · 2018Article
- An investigation of doubt in obsessive-compulsive disorder.Comprehensive psychiatry · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The diagnosis of obsessive-compulsive disorder (OCD) is based on the presence of specific symptoms and their consequence in the lives of those that exhibit them. It is likely that these symptoms emerge from a neurocognitive vulnerability in the mental life of the individual which has a basis in neurophysiology. The prominence of doubt/uncertainty/lack of confidence (These terms are used interchangeably in this paper.), in the clinical presentation of many patients suffering from OCD leads to our consideration of the cognitive basis for this phenomenon. In this paper, we propose that OCD emerges from a perturbation in the decision-making process. Specifically, we hypothesize that there is diminished confidence, conviction, or certainty with regard to assimilating the information necessary to reach a decision. Recent advances in the neuroscience of decision-making provide an opportunity to further our understanding of the vulnerability underlying OCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.