ArticleScientific reports2016
Proliferation and osteogenic differentiation of rat BMSCs on a novel Ti/SiC metal matrix nanocomposite modified by friction stir processing.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing.Molecular medicine reports · 2026Article
- The Effect of Titanium Dioxide Nanotubes and Graphene Compounds on the Proliferation and Osteogenic Differentiation of Rat BMSCs.Journal of functional biomaterials · 2025Article
- Development, characterization and biological studies of Mn-doped ZnO/Ti biomaterials for regenerative medicine.Scientific reports · 2025Article
- Characterisation of AZ31/TiC composites fabricated via ultrasonic vibration assisted friction stir processing.Scientific reports · 2024Article
- Review
- A 3D-Printed Scaffold for Repairing Bone Defects.Polymers · 2024Review
- A phase-transited lysozyme coating doped with strontium on titanium surface for bone repairing via enhanced osteogenesis and immunomodulatory.Frontiers in cell and developmental biology · 2024Article
- A Novel Nanostructured Surface on Titanium Implants Increases Osseointegration in a Sheep Model.Clinical orthopaedics and related research · 2022Article
- Biodegradability and Cytocompatibility of 3D-Printed Mg-Ti Interpenetrating Phase Composites.Frontiers in bioengineering and biotechnology · 2022Article
- Total flavonoids ofMolecular medicine reports · 2021Article
- Metal Material, Properties and Design Methods of Porous Biomedical Scaffolds for Additive Manufacturing: A Review.Frontiers in bioengineering and biotechnology · 2021Review
- Multi-Scale Surface Treatments of Titanium Implants for Rapid Osseointegration: A Review.Nanomaterials (Basel, Switzerland) · 2020Review
- Influence of Isothermal ω Transitional Phase-Assisted Phase Transition From β to α on Room-Temperature Mechanical Performance of a Meta-Stable β Titanium Alloy Ti-10Mo-6Zr-4Sn-3Nb (Ti-B12) for Medical Application.Frontiers in bioengineering and biotechnology · 2020Article
- Functional Gradient Metallic Biomaterials: Techniques, Current Scenery, and Future Prospects in the Biomedical Field.Frontiers in bioengineering and biotechnology · 2020Review
- Research Progress of Titanium-Based High Entropy Alloy: Methods, Properties, and Applications.Frontiers in bioengineering and biotechnology · 2020Review
- Surface Modification Techniques of Titanium and its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review.Frontiers in bioengineering and biotechnology · 2020Review
- A Magnesium-Incorporated Nanoporous Titanium Coating for Rapid Osseointegration.International journal of nanomedicine · 2020Article
- Nano-Modified Titanium Implant Materials: A Way Toward Improved Antibacterial Properties.Frontiers in bioengineering and biotechnology · 2020Review
- Gradient Microstructures and Mechanical Properties of Ti-6Al-4V/Zn Composite Prepared by Friction Stir Processing.Materials (Basel, Switzerland) · 2019Article
- Microstructures, mechanical, and biological properties of a novel Ti-6V-4V/zinc surface nanocomposite prepared by friction stir processing.International journal of nanomedicine · 2018Article
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Authors and funding
7 authors.
Funding
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Abstract
The aims of this study were to fabricate a novel titanium/silicon carbide (Ti/SiC) metal matrix nanocomposite (MMNC) by friction stir processing (FSP) and to investigate its microstructure and mechanical properties. In addition, the adhesion, proliferation and osteogenic differentiation of rat bone marrow stromal cells (BMSCs) on the nanocomposite surface were investigated. The MMNC microstructure was observed by both scanning and transmission electron microscopy. Mechanical properties were characterized by nanoindentation and Vickers hardness testing. Integrin β1 immunofluorescence, cell adhesion, and MTT assays were used to evaluate the effects of the nanocomposite on cell adhesion and proliferation. Osteogenic and angiogenic differentiation were evaluated by alkaline phosphatase (ALP) staining, ALP activity, PCR and osteocalcin immunofluorescence. The observed microstructures and mechanical properties clearly indicated that FSP is a very effective technique for modifying Ti/SiC MMNC to contain uniformly distributed nanoparticles. In the interiors of recrystallized grains, characteristics including twins, fine recrystallized grains, and dislocations formed concurrently. Adhesion, proliferation, and osteogenic and angiogenic differentiation of rat BMSCs were all enhanced on the novel Ti/SiC MMNC surface. In conclusion, nanocomposites modified using FSP technology not only have superior mechanical properties under stress-bearing conditions but also provide improved surface and physicochemical properties for cell attachment and osseointegration.
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