ArticleScientific reports2016
High-resolution short-exposure small-animal laboratory x-ray phase-contrast tomography.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Visualisation of gene expression within the context of tissues using an X-ray computed tomography-based multimodal approach.Scientific reports · 2024Article
- Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish.Cardiovascular research · 2022Article
- Brain virtual histology with X-ray phase-contrast tomography Part I: whole-brain myelin mapping in white-matter injury models.Biomedical optics express · 2022Article
- A phase-retrieval toolbox for X-ray holography and tomography.Journal of synchrotron radiation · 2020Article
- Visualization of internal 3D structure of small live seed on germination by laboratory-based X-ray microscopy with phase contrast computed tomography.Plant methods · 2020Article
- An interactive and intuitive visualisation method for X-ray computed tomography data of biological samples in 3D Portable Document Format.Scientific reports · 2019Article
- Quantification of image texture in X-ray phase-contrast-enhanced projection images of in vivo mouse lungs observed at varied inflation pressures.Physiological reports · 2019Article
- Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography.Journal of visualized experiments : JoVE · 2018Article
- A quantitative analysis of 3D-cell distribution in regenerating muscle-skeletal system with synchrotron X-ray computed microtomography.Scientific reports · 2018Article
- Application of a novel in vivo imaging approach to measure pulmonary vascular responses in mice.Physiological reports · 2018Article
- Cellular-resolution 3D virtual histology of human coronary arteries using x-ray phase tomography.Scientific reports · 2018Article
- Three-dimensional virtual histology of human cerebellum by X-ray phase-contrast tomography.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- High-resolution μCT of a mouse embryo using a compact laser-driven X-ray betatron source.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Implementation of a double-grating interferometer for phase-contrast computed tomography in a conventional system nanotomAPL bioengineering · 2018Article
- Propagation-based Phase-Contrast X-ray Imaging at a Compact Light Source.Scientific reports · 2017Article
- Novel imaging approaches for small animal models of lung disease (2017 Grover Conference series).Pulmonary circulationArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
X-ray computed tomography of small animals and their organs is an essential tool in basic and preclinical biomedical research. In both phase-contrast and absorption tomography high spatial resolution and short exposure times are of key importance. However, the observable spatial resolutions and achievable exposure times are presently limited by system parameters rather than more fundamental constraints like, e.g., dose. Here we demonstrate laboratory tomography with few-ten μm spatial resolution and few-minute exposure time at an acceptable dose for small-animal imaging, both with absorption contrast and phase contrast. The method relies on a magnifying imaging scheme in combination with a high-power small-spot liquid-metal-jet electron-impact source. The tomographic imaging is demonstrated on intact mouse, phantoms and excised lungs, both healthy and with pulmonary emphysema.
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