ArticleScientific reports2016
Wnt Ligands Differentially Regulate Toxicity and Translocation of Graphene Oxide through Different Mechanisms in Caenorhabditis elegans.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Engineering the surface of graphene oxide with bovine serum albumin for improved biocompatibility inNanoscale advances · 2020Article
- Stable isotope labeling of metal/metal oxide nanomaterials for environmental and biological tracing.Nature protocols · 2019Article
- Dysregulation of Neuronal Gαo Signaling by Graphene Oxide in Nematode Caenorhabditis elegans.Scientific reports · 2019Article
- Deficit in the epidermal barrier induces toxicity and translocation of PEG modified graphene oxide in nematodes.Toxicology research · 2018Article
- Biosafety assessment of water samples from Wanzhou watershed of Yangtze Three Gorges Reservior in the quiet season in Caenorhabditis elegans.Scientific reports · 2018Article
- Developmental basis for intestinal barrier against the toxicity of graphene oxide.Particle and fibre toxicology · 2018Article
- Identification of interneurons required for the aversive response of Caenorhabditis elegans to graphene oxide.Journal of nanobiotechnology · 2018Article
- Graphene Oxide Dysregulates Neuroligin/NLG-1-Mediated Molecular Signaling in Interneurons in Caenorhabditis elegans.Scientific reports · 2017Article
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5 authors.
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Abstract
In this study, we investigated the possible involvement of Wnt signals in the control of graphene oxide (GO) toxicity using the in vivo assay system of Caenorhabditis elegans. In nematodes, the Wnt ligands, CWN-1, CWN-2, and LIN-44, were found to be involved in the control of GO toxicity. Mutation of cwn-1 or lin-44 gene induced a resistant property to GO toxicity and resulted in the decreased accumulation of GO in the body of nematodes, whereas mutation of cwn-2 gene induces a susceptible property to GO toxicity and an enhanced accumulation of GO in the body of nematodes. Genetic interaction assays demonstrated that mutation of cwn-1 or lin-44 was able to suppress the susceptibility to GO toxicity shown in the cwn-2 mutants. Loss-of-function mutations in all three of these Wnt ligand genes resulted in the resistance of nematodes to GO toxicity. Moreover, the Wnt ligands might differentially regulate the toxicity and translocation of GO through different mechanisms. These findings could be important in understanding the function of Wnt signals in the regulation of toxicity from environmental nanomaterials.
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