Observational studyThe American journal of gastroenterology2017
Distinct Abnormalities of Small Bowel and Regional Colonic Volumes in Subtypes of Irritable Bowel Syndrome Revealed by MRI.
Observational study in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- A Systematic Review of Technical Parameters for MR of the Small Bowel in non-IBD Conditions over the Last Ten Years.Scientific reports · 2019Pooled it
- Low-FODMAPWorld journal of gastroenterology · 2018Trial
- Correlation between Constipation Symptoms and Abdominal CT Imaging: A Cross-Sectional Pilot Study.Journal of clinical medicine · 2023Article
- Colonic volume in patients with functional constipation or irritable bowel syndrome determined by magnetic resonance imaging.Neurogastroenterology and motility · 2022Article
- Mechanisms Underlying Food-Triggered Symptoms in Disorders of Gut-Brain Interactions.The American journal of gastroenterology · 2022Review
- Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI.Diagnostics (Basel, Switzerland) · 2021Article
- Evidence-based clinical practice guidelines for irritable bowel syndrome 2020.Journal of gastroenterology · 2021Article
- Feasibility Study of a New Magnetic Resonance Imaging Mini-capsule Device to Measure Whole Gut Transit Time in Paediatric Constipation.Journal of pediatric gastroenterology and nutrition · 2020Article
- Imaging Measurement of Whole Gut Transit Time in Paediatric and Adult Functional Gastrointestinal Disorders: A Systematic Review and Narrative Synthesis.Diagnostics (Basel, Switzerland) · 2019Review
- A high prevalence of chronic gastrointestinal symptoms in adults with cystic fibrosis is detected using tools already validated in other GI disorders.United European gastroenterology journal · 2019Article
- MRI of the Colon in the Pharmaceutical Field: The Future before us.Pharmaceutics · 2019Review
- Review of the role of abdominal imaging in irritable bowel syndrome.World journal of radiology · 2018Review
- Gastrointestinal Gas and Abdominal Fat Quantity Measured by Three-Dimensional Abdominal Computed Tomography in Patients with Functional Bloating.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2018Article
- Colonic transit time and pressure based on Bernoulli's principle.Clinical and experimental gastroenterology · 2018Article
- The global impact of IBS: time to think about IBS-specific models of care?Therapeutic advances in gastroenterology · 2017Review
- Response to Uno.The American journal of gastroenterology · 2017Article
- Enigma of Intestinal Gas in Irritable Bowel Syndrome.The American journal of gastroenterology · 2017Article
- Small Bowel Motility.Current gastroenterology reports · 2017Review
Corrections and comments
- Commented on by
- Commented on byResponse to Uno.2017
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesNon-invasive biomarkers which identify different mechanisms of disease in subgroups of irritable bowel syndrome (IBS) could be valuable. Our aim was to seek useful magnetic resonance imaging (MRI) parameters that could distinguish each IBS subtypes.
methods34 healthy volunteers (HV), 30 IBS with diarrhea (IBS-D), 16 IBS with constipation (IBS-C), and 11 IBS with mixed bowel habit (IBS-M) underwent whole-gut transit and small and large bowel volumes assessment with MRI scans from t=0 to t=360 min. Since the bowel frequency for IBS-M were similar to IBS-D, IBS-M and IBS-D were grouped together and labeled as IBS non-constipation group (IBS-nonC).
resultsMedian (interquartile range): fasting small bowel water content in IBS-nonC was 21 (10-42), significantly less than HV at 44 ml (15-70), P<0.01 as was the postprandial area under the curve (AUC) P<0.01. The fasting transverse colon volumes in IBS-C were significantly larger at 253 (200-329) compared with HV, IBS-nonC whose values were 165 (117-255) and 198 (106-270) ml, respectively, P=0.02. Whole-gut transit time for IBS-C was prolonged at 69 (51-111), compared with HV at 34 (4-63) and IBS-D at 34 (17-78) h, P=0.03. Bloating score (VAS 0-10 cm) correlated with transverse colon volume at t=405 min, Spearman r=0.21, P=0.04.
conclusionsThe constricted small bowel in IBS-nonC and the dilated transverse colon in IBS-C point to significant differences in underlying mechanisms of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.