Evidence map›Paper›PMID 27957685›Full record

ArticleMolecular neurobiology2018

TRPM2 Promotes Neurotoxin MPP

Yuyang Sun, Pramod Sukumaran, Senthil Selvaraj, Nicholas I Cilz, Anne Schaar, Saobo Lei, Brij B Singh

Abstract read
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Oxidative Stress in Brain Function.Antioxidants (Basel, Switzerland) · 2025
    Review
  8. Article
  9. [Advances in the development of transient receptor potential melastatin 2 channel inhibitors].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  10. Studying the mechanisms of neurodegeneration:Frontiers in cellular neuroscience · 2025
    Review
  11. Article
  12. Article
  13. NOX2-TRPM2 coupling promotes ZnScientific reports · 2024
    Article
  14. Transient Receptor Potential Channels in the Healthy and Diseased Blood-Brain Barrier.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuyang SunDepartment of Biomedical Science, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58201, USA.
Pramod SukumaranDepartment of Biomedical Science, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58201, USA.
Senthil SelvarajDepartment of Biomedical Science, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58201, USA.
Nicholas I CilzDepartment of Biomedical Science, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58201, USA.
Anne SchaarDepartment of Biomedical Science, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58201, USA.
Saobo LeiDepartment of Biomedical Science, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58201, USA.
Brij B SinghDepartment of Biomedical Science, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58201, USA. brij.singh@med.und.edu.
University of North Dakota · US

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Donald A. Sens · 2012 to 2026
$53.0M
Yersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2016 to 2025
$19.9M
TRPC1, Calcium, and Saliva SecretionR01DE017102 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Brij B Singh · 2006 to 2026
$7.5M
Galectins as novel alarmins in salivary gland inflammationR21DE024300 · NIDCR · UNIVERSITY OF NORTH DAKOTA · PI MISHRA, BIBHUTI BHUSAN, SINGH, BRIJ B · 2015 to 2016
$382k
NIDCR NIH HHS DE017102NIDCR NIH HHS DE024300NIDCR NIH HHS R01 DE017102NIDCR NIH HHS R21 DE024300NIGMS NIH HHS GM103442NIGMS NIH HHS GM113123NIGMS NIH HHS P20 GM103442NIGMS NIH HHS P20 GM113123
6 · The paper itself

Abstract

In neurons, Ca

Indexed as

1-Methyl-4-phenylpyridiniumAgedAnimalsCell DeathCell Line, TumorCell SurvivalDopaminergic NeuronsFemaleHerbicidesHumansMaleMiceMice, Inbred C57BLMPTP PoisoningParkinson DiseaseTRPM Cation Channels1-Methyl-4-phenylpyridiniumHerbicidesTRPM2 protein, mouseTRPM Cation ChannelsApoptosisCalciumMPTP/MPP+Oxidative stressROSTRPM2

Identifiers

PMID27957685
PMCPMC5468501
OpenAlexW2563900680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.