ReviewMolecular imaging and biology2017
Dosimetry in Micro-computed Tomography: a Review of the Measurement Methods, Impacts, and Characterization of the Quantum GX Imaging System.
Review in Molecular imaging and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment.Signal transduction and targeted therapy · 2025Trial
- Comparing the Achievable Sensitivity Limits of Synchrotron-based X-ray Fluorescence Imaging versus conventional X-ray absorption imaging and comparing absorbed dose levels including PET/SPECT.Zeitschrift fur medizinische Physik · 2026Review
- Material Composition and Implantation Site Affect in vivo Device Degradation Rate.Research square · 2026Article
- Development of a method for evaluation of absorbed doses in preclinical in vivo μCT.Radiation protection dosimetry · 2025Article
- Article
- Hydrophilic Particles Exit While Hydrophobic Particles Persist Following In Vivo Biodegradation of Nanoparticle-Laden Polymeric Devices.Advanced nanobiomed research · 2025Article
- Contrast-to-noise ratio comparison between X-ray fluorescence emission tomography and computed tomography.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Computed tomography technologies to measure key structural features of polymeric biomedical implants from bench to bedside.Journal of biomedical materials research. Part A · 2024Article
- Material Composition and Implantation Site Affect in vivo Device Degradation Rate.bioRxiv : the preprint server for biology · 2024Article
- In vivo micro-computed tomography evaluation of radiopaque, polymeric device degradation in normal and inflammatory environments.Acta biomaterialia · 2024Article
- Multiphase micro-computed tomography reconstructions provide dynamic respiratory function in a mouse lung fibrosis model.iScience · 2024Article
- In vivo Biomedical Imaging of Immune Tolerant, Radiopaque Nanoparticle-Embedded Polymeric Device Degradation.bioRxiv : the preprint server for biology · 2023Article
- The DAging cell · 2023Article
- Incorporating Tantalum Oxide Nanoparticles into Implantable Polymeric Biomedical Devices for Radiological Monitoring.Advanced healthcare materials · 2023Article
- A fully automated micro‑CT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy.Respiratory research · 2023Article
- Ultrahigh resolution whole body photon counting computed tomography as a novel versatile tool for translational research from mouse to man.Zeitschrift fur medizinische Physik · 2023Article
- Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice.Nature protocols · 2023Review
- A fully automated deep learning pipeline for micro-CT-imaging-based densitometry of lung fibrosis murine models.Respiratory research · 2022Article
- The importance of routine quality control for reproducible pulmonary measurements by in vivo micro-CT.Scientific reports · 2022Article
- CT vs. bioluminescence: A comparison of imaging techniques for orthotopic prostate tumors in mice.PloS one · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeX-ray micro-computed tomography (μCT) is a widely used imaging modality in preclinical research with applications in many areas including orthopedics, pulmonology, oncology, cardiology, and infectious disease. X-rays are a form of ionizing radiation and, therefore, can potentially induce damage and cause detrimental effects. Previous reviews have touched on these effects but have not comprehensively covered the possible implications on study results. Furthermore, interpreting data across these studies is difficult because there is no widely accepted dose characterization methodology for preclinical μCT. The purpose of this paper is to ensure in vivo μCT studies can be properly designed and the data can be appropriately interpreted. PROCEDURES: Studies from the scientific literature that investigate the biological effects of radiation doses relevant to μCT were reviewed. The different dose measurement methodologies used in the peer-reviewed literature were also reviewed. The CT dose index 100 (CTDI
resultsData in the scientific literature indicate that scenarios exist where radiation doses used in μCT imaging are high enough to potentially bias experimental results. The significance of this effect may relate to the study outcome and tissue being imaged. CTDI
conclusionsDose management should be considered when designing μCT studies. Dose rates in the Quantum GX are compatible with longitudinal μCT imaging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.