ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2017
Epileptic seizure, as the first symptom of hypoparathyroidism in children, does not require antiepileptic drugs.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Article
- Primary hypoparathyroidism: hypocalcaemia misdiagnosed as epilepsy.BMJ case reports · 2023Article
- Idiopathic Hypoparathyroidism Presenting As New Onset Refractory Status Epilepticus.Journal of neurosciences in rural practice · 2021Article
- Article
- Reversible central neural hyperexcitability: an electroencephalographic clue to hypocalcaemia.BMJ case reports · 2017Article
- EPILEPTIC SEIZURES AS THE FIRST MANIFESTATION OF FAHR'S SYNDROME.Acta endocrinologica (Bucharest, Romania : 2005)Article
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5 authors at 3 institutions in 1 country.
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Abstract
objectivePatients with hypoparathyroidism exhibit metabolic disorders (hypocalcemia) and brain structural abnormalities (brain calcifications). Currently, studies have determined whether antiepileptic drug (AED) treatment is required for epileptic seizures in children with hypoparathyroidism.
methodThis study aims to evaluate the data of two medical centers in Beijing based on the diagnosis of epileptic seizures as the first symptom of hypoparathyroidism in children.
resultA total of 42 patients were included and assigned into AED and non-AED treatment groups in a 1:2 matched case-control study. Results show that the seizure outcome after 1 year of AED treatment is not significantly different from that of the control. In the subgroup analysis of patients with subcortical calcifications, the seizure outcome is still not significantly different from that of the control.
conclusionThus, AED treatment cannot improve the seizure outcomes in children with parathyroid disorder, even in such cases as suspected structural seizure caused by subcortical calcifications. Clinicians must take adequate considerations on the use of AEDs in these patients. Epileptic seizures, as the first symptom of hypoparathyroidism in children, do not require epilepsy drugs.
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