ArticleEuropean journal of radiology open2016
Standard-dose vs. low-dose CT protocols in the evaluation of localized lung lesions: Capability for lesion characterization-iLEAD study.
Article in European journal of radiology open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Comparing the detectability of pulmonary nodules on two ultra-high resolution CT scanners: a preliminary phantom study.European radiology · 2026Article
- Image-domain deep learning denoising for low-dose chest CT on a single 128-slice CT platform: a retrospective image-quality assessment.Frontiers in medicine · 2026Article
- Impact of a deep-learning image reconstruction algorithm on image quality and detection of solid lung lesions.Research in diagnostic and interventional imaging · 2025Article
- Low Dose Contrast Enhanced CT Thorax Protocol: Comparison of Low Kilovoltage, Low Contrast Volume Using Iterative Reconstruction Technique with Standard Protocol.Ethiopian journal of health sciences · 2025Article
- Deep Learning-Based Reconstruction Algorithm With Lung Enhancement Filter for Chest CT: Effect on Image Quality and Ground Glass Nodule Sharpness.Korean journal of radiology · 2024Article
- Accuracy of patient-specific CT organ doses from Monte Carlo simulations: influence of CT-based voxel models.Physical and engineering sciences in medicine · 2024Article
- Deep Learning Image Reconstruction for CT: Technical Principles and Clinical Prospects.Radiology · 2023Review
- Sequential low-dose CT thorax scans to determine invasive pulmonary fungal infection incidence after allogeneic hematopoietic cell transplantation.Annals of hematology · 2023Observational
- Image Recovery from Synthetic Noise Artifacts in CT Scans Using Modified U-Net.Sensors (Basel, Switzerland) · 2022Article
- A Task-dependent Investigation on Dose and Texture in CT Image Reconstruction.IEEE transactions on radiation and plasma medical sciences · 2020Article
- Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients.Journal of fungi (Basel, Switzerland) · 2020Article
- A Feasibility Study of Extracting Tissue Textures From a Previous Full-Dose CT Database as Prior Knowledge for Bayesian Reconstruction of Current Low-Dose CT Images.IEEE transactions on medical imaging · 2019Article
- Video-assisted thoracoscopic surgery for invasive pulmonary fungal infection in haematology patients.Journal of thoracic disease · 2019Article
- Imaging Cancer Metabolism.Biomolecules & therapeutics · 2018Review
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Authors and funding
9 authors.
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Abstract
objectiveTo determine the lesion characterization capability by low dose CT for localized lung lesions in comparison with standard dose CT. SUBJECTS AND
methodsApproval for this study was granted by our Institutional Review Board. Fifty-two consecutive patients (36 males and 16 females, median age of 71 years.) who had CT examinations for evaluation of lung lesions comprise the study population. Two chest CT scans were performed with current time product of 50 and 150 mAs at 120 kVp, with the same scan length with a 16 detector-row CT scanner. Three readers evaluated 52 target lesions and assigned an overall impression score to each target lesion, using a 5 point scale from 1 (definitely benign) to 5 (definitely malignant). Six features of the lesions including lesion type, margin characteristics, calcification, lobulation, speculation, and pleural indentation were also reported with 5-point scales. The weighted kappa analyses and receiver operating characteristic analysis were used for analysis.
resultsThe mean kappa value between low-and standard-dose CT was 0.82 for overall impression of the lesions, showing almost perfect agreement. Area under the curve of low-dose CT (Az = 0.74) had no significant difference from that of standard-dose CT (Az = 0.74) (p = 0.61). The kappa values for six lesion features ranged from 0.45 to 0.83, showing moderate to almost perfect agreement.
conclusionLesion characterization capability by low-dose CT images was comparable to that by standard-dose CT images and therefore sufficient for evaluation of localized lung lesions.
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