ArticleIranian journal of public health2016
Can Opium Use Contribute to a Higher Risk of Colorectal Cancers? A Matched Case-control Study in Iran.
Article in Iranian journal of public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The significant impact of opium use on various types of cancer: an updated - systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Prevalence of tobacco use among cancer patients in Iran: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Opium Use and Cancer Risk: A Comprehensive Systematic Review and Meta-Analysis of Observational Studies.International journal of clinical practice · 2022Pooled it
- Incidence and Risk Factors of Colorectal Cancer in the Iranian Population: a Systematic Review.Journal of gastrointestinal cancer · 2021Pooled it
- Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationPooled it
- Article
- Colorectal Cancer Screening Among Individuals With a Substance Use Disorder: A Retrospective Cohort Study.AJPM focus · 2024Article
- Opium use and gastrointestinal cancers: a systematic review and meta-analysis study.Gastroenterology and hepatology from bed to bench · 2024Review
- Trends of colorectal cancer in a central area of Iran during 2009-2014. An application of joinpoint regression.Contemporary oncology (Poznan, Poland) · 2022Article
- Opium as a carcinogen: A systematic review and meta-analysis.EClinicalMedicine · 2021Article
- Is opium use associated with an increased risk of lung cancer? A case-control study.BMC cancer · 2020Observational
- Opium and risk of gastrointestinal cancer: a case-control studyTurkish journal of medical sciences · 2020Article
- Opium Use and Head and Neck Cancers: A Matched Case-Control Study in Iran.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Opioid-induced immunosuppression and carcinogenesis promotion theories create the newest trend in acute and chronic pain pharmacotherapy.Clinics (Sao Paulo, Brazil) · 2020Review
- The independent and combined effects of selected risk factors and Arg399Gln XRCC1 polymorphism in the risk of colorectal cancer among an Iranian population.Medical journal of the Islamic Republic of Iran · 2020Article
- Is Pouch Specific to Colon and Not Ileum?Current pediatric reviews · 2019Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancers (CRCs) including colon, rectum and anal cancers are the third most prevalent cancers in the world. There are strong evidence showing the risk of the cigarette smoking, alcohol use, low physical activity and some types of diets in CRCs; however, few studies explored the relationship between opium use and CRCs. This study aimed to investigate the association between opioid use and the incidence of CRCs.
methodsIn a population-based matched case-control study in Kerman, Iran, 175 patients with colorectal cancers and 350 healthy controls (matched for age, sex, and place of residence) were interviewed from Sep 2014 to Nov 2014. Opium and its derivatives, cigarette, alcohol, and diet use were collected using a valid and reliable questionnaire. Conditional logistic regression was used to estimate odds ratios with 95% confidence intervals.
resultsThe use of opioids was associated with an increased risk of CRCs (adjusted odds ratio= 4. 5, 95% CI: 2. 4-8. 7). In addition, a dose-response relationship was observed between the cumulative use of opioids and the incidence of CRCs (with low use OR=3. 7; 95% CI: 1. 5-8. 6 and high use OR= 8. 0; 95% CI: 2. 9-21. 7). This dose-response relationship was also strong in patients with colon cancers, with OR= 3. 9 (95% CI: 1. 5-9. 9) and 9. 4 (95% CI: 3. 3-27. 0) for the low and high uses of opioids, respectively.
conclusionOpioid use can lead to an increased risk of CRCs. Therefore, it is necessary to implement preventive policies to control the use of opioids.
Indexed as
Identifiers
27957439PMC5149496What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.