Evidence map›Paper›PMID 27956946›Full record

ArticleGastroenterology research2009

Protective Effects of Proanthocyanidin on Cerulein-induced Acute Pancreatic Inflammation in Rats.

Cebrail Akyuz, Ahmet Ozer Sehirli, Umit Topaloglu, Ayliz Velioglu Ogunc, Sule Cetinel, Goksel Sener

Open access · hybridAbstract read
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In one paragraph

Article in Gastroenterology research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. CashewAntioxidants (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cebrail AkyuzDepartment of 5 Surgery, Haydarpasa Numune Education and Research Hospital.
Ahmet Ozer SehirliMarmara University, School of Pharmacy, Department of Pharmacology.
Umit TopalogluDepartment of 5 Surgery, Haydarpasa Numune Education and Research Hospital.
Ayliz Velioglu OguncMarmara University, Vocational School of Health Related Professions.
Sule CetinelMarmara University, School of Medicine, Department of Histology & Embryology, Istanbul, Turkey.
Goksel SenerDepartment of 5 Surgery, Haydarpasa Numune Education and Research Hospital.
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to assess the possible protective effect of proanthocyanidin against cerulein-induced acute pancreatic inflammation (AP) and oxidative injury.

methodsSprague-Dawley rats were pretreated with proanthocyanidine (100 mg/kg, orally) or saline 15 min before cerulein was given by 20 µg/kg subcutaneously at 1-h intervals within 4 hours. Six hours after cerulein or saline injections, the animals were killed by decapitation. Blood samples were collected to analyze amylase, lipase, and proinflammatory cytokines (TNF-α and IL-1b). Pancreas tissues were taken for the determination of tissue glutathione (GSH) and malondialdehyde (MDA) levels, Na

resultsAcute pancreatitis caused a significant decrease in tissue GSH level and Na

conclusionsProanthocyanidine can ameliorate pancreatic injury induced by cerulein in rats, this result suggests that proanthocyanidin may have utility in treating acute pancreatititis.

Indexed as

CytokinesGlutathioneMyeloperoxidase activityPancreatitisProanthocyanidineTumor Necrosis Factor alpha

Identifiers

PMID27956946
PMCPMC5139881
OpenAlexW2009461812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.