ArticleMolecular psychiatry2017
Schizophrenia copy number variants and associative learning.
Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study.Molecular psychiatry · 2021Pooled it
- Memory-Associated Immediate Early Genes: Roles in Synaptic Function, Memory Processes, and Neurological Diseases.Molecular neurobiology · 2025Review
- Reinstatement of nicotine conditioned place preference in a transgenerational model of drug abuse vulnerability in psychosis: Impact of BDNF on the saliency of drug associations.Psychopharmacology · 2023Article
- Copy Number Variations and Schizophrenia.Molecular neurobiology · 2023Review
- Schizophrenia Genomics: Convergence on Synaptic Development, Adult Synaptic Plasticity, or Both?Biological psychiatry · 2022Review
- Psychedelic drug use and schizotypy in young adults.Scientific reports · 2021Article
- Genetic association of FMRP targets with psychiatric disorders.Molecular psychiatry · 2021Article
- RB1CC1 duplication and aberrant overexpression in a patient with schizophrenia: further phenotype delineation and proposal of a pathogenetic mechanism.Molecular genetics & genomic medicine · 2021Article
- Cacna1c Hemizygosity Results in Aberrant Fear Conditioning to Neutral Stimuli.Schizophrenia bulletin · 2020Article
- Learning to predict pain: differences in people with persistent neck pain and pain-free controls.PeerJ · 2020Article
- The effect of ketamine on the consolidation and extinction of contextual fear memory.Journal of psychopharmacology (Oxford, England) · 2018Article
- Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies.British journal of pharmacology · 2017Review
- Schizophrenia and the dynamic genome.Genome medicine · 2017Review
- Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning.Neural plasticity · 2017Article
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Authors and funding
11 authors.
Funding
Abstract
Large-scale genomic studies have made major progress in identifying genetic risk variants for schizophrenia. A key finding from these studies is that there is an increased burden of genomic copy number variants (CNVs) in schizophrenia cases compared with controls. The mechanism through which these CNVs confer risk for the symptoms of schizophrenia, however, remains unclear. One possibility is that schizophrenia risk CNVs impact basic associative learning processes, abnormalities of which have long been associated with the disorder. To investigate whether genes in schizophrenia CNVs impact on specific phases of associative learning we combined human genetics with experimental gene expression studies in animals. In a sample of 11 917 schizophrenia cases and 16 416 controls, we investigated whether CNVs from patients with schizophrenia are enriched for genes expressed during the consolidation, retrieval or extinction of associative memories. We show that CNVs from cases are enriched for genes expressed during fear extinction in the hippocampus, but not genes expressed following consolidation or retrieval. These results suggest that CNVs act to impair inhibitory learning in schizophrenia, potentially contributing to the development of core symptoms of the disorder.
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