ArticleMolecular psychiatry2017
Altered brain processing of decision-making in healthy first-degree biological relatives of suicide completers.
Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Decision-making and cognitive control in adolescent suicidal behaviors: a qualitative systematic review of the literature.European child & adolescent psychiatry · 2021Pooled it
- Association of Polygenic Risk Score for Suicidal Behavior With Ventral Prefrontal Morphology in Bipolar Disorder.Bipolar disorders · 2026Article
- Suicide risk among individuals admitted to an acute psychiatric ward: clinical characteristics, attachment pattern and dignity perception.Frontiers in psychiatry · 2026Article
- Risk, reward, and suicide: how impulsivity and loss aversion influence decision-making in individuals who have attempted suicide.Frontiers in psychiatry · 2026Article
- Neural correlates of decision making and executive function in suicidal thoughts and behaviors.Frontiers in psychiatry · 2025Review
- Perception of social inclusion/exclusion and response inhibition in adolescents with past suicide attempt: a multidomain task-based fMRI study.Molecular psychiatry · 2024Article
- Dorsal and ventral fronto-amygdala networks underlie risky decision-making in age-related cognitive decline.GeroScience · 2024Article
- Predicting suicidality in late-life depression by 3D convolutional neural network and cross-sample entropy analysis of resting-state fMRI.Brain and behavior · 2024Article
- Neural responses to social decision-making in suicide attempters with mental disorders.BMC psychiatry · 2023Article
- Aging-related changes in reward-based decision-making depend on punishment frequency: An fMRI study.Frontiers in aging neuroscience · 2023Article
- Investigating the Clinical Profile of Suicide Attempters Who Used a Violent Suicidal Means.Journal of clinical medicine · 2022Article
- The orbitofrontal cortex represents advantageous choice in the Iowa gambling task.Human brain mapping · 2022Article
- Identifying Changes of Brain Regional Homogeneity and Cingulo-Opercular Network Connectivity in First-Episode, Drug-Naïve Depressive Patients With Suicidal Ideation.Frontiers in neuroscience · 2022Article
- Exploring neurometabolic alterations in bipolar disorder with suicidal ideation based on proton magnetic resonance spectroscopy and machine learning technology.Frontiers in neuroscience · 2022Article
- Prefrontal cortex and depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Functional network alterations differently associated with suicidal ideas and acts in depressed patients: an indirect support to the transition model.Translational psychiatry · 2021Article
- Association between family history of suicide attempt and neurocognitive functioning in community youth.Journal of child psychology and psychiatry, and allied disciplines · 2021Article
- Review
- Atrophy of right inferior frontal orbital gyrus and frontoparietal functional connectivity abnormality in depressed suicide attempters.Brain imaging and behavior · 2020Article
- A Brain-Centric Model of Suicidal Behavior.The American journal of psychiatry · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suicidal behavior is heritable, with the transmission of risk being related to the transmission of vulnerability traits. Previous studies suggest that risky decision-making may be an endophenotype of suicide. Here, we aimed at investigating brain processing of decision-making in relatives of suicide completers in order to shed light on heritable mechanisms of suicidal vulnerability. Seventeen healthy first-degree biological relatives of suicide completers with no personal history of suicidal behavior, 16 relatives of depressed patients without any personal or family history of suicidal behavior, and 19 healthy controls were recruited. Functional 3 T magnetic resonance imaging scans were acquired while participants underwent the Iowa Gambling Task, an economic decision-making test. Whole-brain analyses contrasting activations during risky vs safe choices were conducted with AFNI and FSL. Individuals with a family history of suicide in comparison to control groups showed altered contrasts in left medial orbitofrontal cortex, and right dorsomedial prefrontal cortex. This pattern was different from the neural basis of familial depression. Moreover, controls in comparison to relatives showed increased contrast in several regions including the post-central gyrus, posterior cingulate and parietal cortices, and cerebellum (culmen) in familial suicide; and inferior parietal, temporal, occipital, anteromedial and dorsolateral prefrontal cortices, and cerebellum (vermis) in familial depression. These findings most likely represent a complex combination of vulnerability and protective mechanisms in relatives. They also support a significant role for deficient risk processing, and ventral and dorsal prefrontal cortex functioning in the suicidal diathesis.
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