Evidence map›Paper›PMID 27956704›Full record

ArticleMolecular and cellular biology2017

Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.

Anoush E Anderson, Kenichiro Taniguchi, Yi Hao, Tiffany A Melhuish, Anant Shah, Stephen D Turner, Ann E Sutherland, David Wotton

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly.American journal of medical genetics. Part C, Seminars in medical genetics · 2018
    Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anoush E AndersonDepartment of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia, USA.
Kenichiro TaniguchiDepartment of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia, USA.
Yi HaoDepartment of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia, USA.
Tiffany A MelhuishDepartment of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia, USA.
Anant ShahDepartment of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia, USA.
Stephen D TurnerDepartment of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA.
Ann E SutherlandDepartment of Cell Biology, University of Virginia, Charlottesville, Virginia, USA.
David WottonDepartment of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia, USA dw2p@virginia.edu.
University of Virginia · US

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Thomas P. Loughran · 1987 to 2026
$72.1M
Cancer Research Training Program: From Molecular Mechanisms to Therapeutic StrategiesT32CA009109 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Andrew Carl Dudley, Melanie R Rutkowski · 1985 to 2026
$13.9M
TRAINING IN CELL AND MOLECULAR BIOLOGYT32GM008136 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI STUKENBERG, P. TODD · 1985 to 2020
$8.5M
TROPHOBLAST CELL MOTILITYR01HD034807 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI SUTHERLAND, ANN E · 1998 to 2008
$2.2M
TGF beta regulation of cilium-dependent signalingR01GM099853 · NIGMS · UNIVERSITY OF VIRGINIA · PI WOTTON, DAVID · 2012 to 2015
$1.2M
Tunable White Light Laser Confocal/Spectral Imaging MicroscopyS10RR025616 · NCRR · UNIVERSITY OF VIRGINIA · PI PERIASAMY, AMMASI · 2009 to 2009
$500k
NCI NIH HHS P30 CA044579NCI NIH HHS T32 CA009109NCRR NIH HHS S10 RR025616NICHD NIH HHS R01 HD034807NIGMS NIH HHS R01 GM099853NIGMS NIH HHS T32 GM008136
6 · The paper itself

Abstract

Mouse embryos conditionally lacking Tgif1 and Tgif2 have holoprosencephaly and defects in left-right asymmetry. To identify pathways affected by loss of Tgif function during embryogenesis, we performed transcriptome profiling on whole mouse embryos. Among the genes with altered expression in embryos lacking Tgifs were a number with links to cilium function. One of these,

Indexed as

AnimalsCell LineCiliaEmbryo, MammalianGene Expression ProfilingGene Expression Regulation, DevelopmentalGene OntologyGTPase-Activating ProteinsHedgehog ProteinsHomeodomain ProteinsHumansMiceMice, KnockoutRepressor ProteinsSignal TransductionTranscription FactorsEVI5L protein, humanEvi5l protein, mouseGTPase-Activating ProteinsHedgehog ProteinsHomeodomain ProteinsRepressor ProteinsShh protein, mouseTGIF1 protein, humanTGIF2 protein, humanTG-interacting factor 2, mouseTranscription FactorsciliumEvi5lregulation of gene expressionTgifTgif1Tgif2transcription factors

Identifiers

PMID27956704
PMCPMC5311242
OpenAlexW2566318317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.