Evidence map›Paper›PMID 27956701›Full record

ArticleMolecular and cellular biology2017

The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence.

Richard Graveline, Katarzyna Marcinkiewicz, Seyun Choi, Marilène Paquet, Wolfgang Wurst, Thomas Floss, Gregory David

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Richard GravelineNew York University School of Medicine, New York, New York, USA.
Katarzyna MarcinkiewiczNew York University School of Medicine, New York, New York, USA.
Seyun ChoiNew York University School of Medicine, New York, New York, USA.
Marilène PaquetFaculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada.
Wolfgang WurstHelmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Thomas FlossHelmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Gregory DavidNew York University School of Medicine, New York, New York, USA gregory.david@nyumc.org.
New York University · USHelmholtz Zentrum München · DEUniversité de Montréal · CA

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
TRAINING PROGRAM IN MOLECULAR ONCOLOGY &IMMUNOLOGYT32CA009161 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CARROLL, WILLIAM L., LEVY, DAVID E · 1985 to 2020
$13.3M
Regulation of Cellular Senescence and Oncogenic Transformation by Sin3B.R01CA148639 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DAVID, GREGORY · 2011 to 2015
$2.0M
Role of cell cycle withdrawal in restricting pancreatic cancer progression.R21CA155736 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DAVID, GREGORY · 2012 to 2014
$590k
(PQ1) Cellular senescence as an initiating event in malignant transformationR21CA206013 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DAVID, GREGORY · 2017 to 2018
$373k
NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA148639NCI NIH HHS R21 CA155736NCI NIH HHS R21 CA206013NCI NIH HHS T32 CA009161
6 · The paper itself

Abstract

Pf1, also known as Phf12 (plant homeodomain [PHD] zinc finger protein 12), is a member of the PHD zinc finger family of proteins. Pf1 associates with a chromatin-interacting protein complex comprised of MRG15, Sin3B, and histone deacetylase 1 (HDAC1) that functions as a transcriptional modulator. The biological function of Pf1 remains largely elusive. We undertook the generation of

Indexed as

Cellular Senescence3T3 CellsAnimalsCell NucleolusChromatinChromosomal Proteins, Non-HistoneEmbryo, MammalianEmbryonic DevelopmentFemaleFibroblastsGene OntologyHomeodomain ProteinsMiceOrganelle BiogenesisPregnancyProtein BindingChromatinChromosomal Proteins, Non-HistoneHomeodomain ProteinsPhf12 protein, mouseRepressor ProteinsRNA, RibosomalnucleolusPf1ribosomesenescencetranscription

Identifiers

PMID27956701
PMCPMC5311238
OpenAlexW2562187388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.