Evidence map›Paper›PMID 27956653›Full record

ArticleThe American journal of tropical medicine and hygiene2017

Environmental Enteric Dysfunction and the Fecal Microbiota in Malawian Children.

M Isabel Ordiz, Kevin Stephenson, Sophia Agapova, Kristine M Wylie, Ken Maleta, John Martin, Indi Trehan, Phillip I Tarr, Mark J Manary

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03801317 (The Effect of Bovine Colostrum/ Egg Supplementation in Young Malawian Children), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03801317 nacompletednot on this mapstarted 2018, after this paper: background citation

The Effect of Bovine Colostrum/ Egg Supplementation in Young Malawian Children

TypeinterventionalSponsorWashington University School of MedicineRan2018 to 2020Enrolled278ConditionsStunting, Environmental Enteric DysfunctionArmsBC/ egg, Control, multiple micronutrient
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. NADScience translational medicine · 2024
    Article
  7. Article
  8. Current research in microbial sciences · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

M Isabel OrdizDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Kevin StephensonDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Sophia AgapovaDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Kristine M WylieDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Ken MaletaDepartment of Community Health, College of Medicine, University of Malawi, Malawi, Africa.
John MartinThe McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri.
Indi TrehanDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Phillip I TarrDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Mark J ManaryDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri. manary@kids.wustl.edu.
Washington University in St. Louis · USJames S. McDonnell Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental enteric dysfunction (EED) is often measured with a dual sugar absorption test and implicated as a causative factor in childhood stunting. Disturbances in the gut microbiota are hypothesized to be a mechanism by which EED is exacerbated, although this supposition lacks support. We performed 16S ribosomal RNA gene sequencing of fecal samples from 81 rural Malawian children with varying degrees of EED to determine which bacterial taxa were associated with EED. At the phyla level, Proteobacteria abundance is reduced with severe EED. Among bacterial genera,

Indexed as

Child DevelopmentChild, PreschoolEnvironmental ExposureFecesFemaleGastrointestinal MicrobiomeGrowth DisordersHumansInfantInfant, NewbornMalawiMaleProteobacteriaRNA, Ribosomal, 16SRural PopulationRNA, Ribosomal, 16S

Identifiers

PMID27956653
PMCPMC5303055
OpenAlexW2561005090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.