ArticleNeurology2016
Ischemic stroke subtypes and migraine with visual aura in the ARIC study.
Article in Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Association between migraine and risk of stroke: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis.Journal of neurology · 2022Pooled it
- Analysis of macular microvasculature with optical coherence tomography angiography for migraine: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Migraine and the risk of cardiovascular and cerebrovascular events: a meta-analysis of 16 cohort studies including 1 152 407 subjects.BMJ open · 2018Pooled it
- Trial
- Migraine and Cardiovascular Risk: A Scoping Review of Vascular Outcomes, Risk Assessment, and Endothelial Dysfunction.Life (Basel, Switzerland) · 2026Review
- Raised intracranial pressure alters cortical vascular function and cephalic allodynia.Brain : a journal of neurology · 2025Article
- Association between liver enzyme levels and prevalence of migraine: the atherosclerosis risk in communities study.Therapeutic advances in neurological disorders · 2025Article
- Migraine is associated with a higher risk of ischemic and hemorrhagic stroke: an analysis of theFrontiers in pain research (Lausanne, Switzerland) · 2025Article
- Migraine and Stroke: A Scoping Review.Journal of clinical medicine · 2024Article
- Microembolism and Other Links Between Migraine and Stroke: Clinical and Pathophysiologic Update.Neurology · 2023Review
- Bibliometric Analysis of Research on Migraine-Stroke Association from 2013 to 2023.Journal of pain research · 2023Article
- Stroke territory and atherosclerosis in ischemic stroke patients with a history of migraine with aura.Frontiers in neurology · 2023Article
- Shorter visual aura characterizes young and middle-aged stroke patients with migraine with aura.Journal of neurology · 2022Article
- Association between migraine and cardiovascular disease: A cross-sectional study.Frontiers in cardiovascular medicine · 2022Article
- Type and Severity of Migraine Determines Risk of Atrial Fibrillation in Women.Frontiers in cardiovascular medicine · 2022Article
- Periodontal Disease, Atrial Fibrillation and Stroke.American heart journal · 2021Article
- Migraine and risk of stroke.Journal of neurology, neurosurgery, and psychiatry · 2020Review
- Arterial ischemic stroke in infants, children, and adolescents: results of a Germany-wide surveillance study 2015-2017.Journal of neurology · 2019Article
- Migraine as a Stroke Mimic and as a Stroke Chameleon.Current pain and headache reports · 2019Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association among migraine, ischemic stroke, and stroke subtypes in the Atherosclerosis Risk in Communities (ARIC) study.
methodsIn this ongoing, prospective, longitudinal community-based cohort study, participants were given an interview ascertaining migraine history in 1993-1995, and were followed for all vascular events, including stroke. All stroke events over the subsequent 20 years were adjudicated and classified into stroke subtypes by standard definitions. Cox proportional hazards models adjusted for stroke risk factors were used to study the relationship between migraine and ischemic stroke, overall, as well as stroke subtypes (cardioembolic, lacunar, or thrombotic).
resultsWe identified 1,622 migraineurs among 12,758 participants. Mean age of the study population at the 3rd clinical visit was 59 years. When compared to nonheadache participants, there was a significant association between migraine with visual aura and ischemic stroke (hazard ratio [HR] 1.7, 95% confidence interval [CI] 1.2-2.6, p = 0.008). Migraine without visual aura was not significantly associated with ischemic stroke (HR 1.2, CI 1.0-1.8, p = 0.28) when compared to nonheadache participants. Among the 3 subtypes of ischemic stroke evaluated, migraine with visual aura was significantly associated only with cardioembolic stroke (HR 3.7, 95% CI 1.6-8.7, p = 0.003).
conclusionIn participants with migraine with visual aura in late middle age, increased risk of cardioembolic stroke was observed. Migraine with visual aura was linked to increased stroke risk, while migraine without visual aura was not, over the period of 20 years. These results are specific to older migraineurs.
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