Evidence map›Paper›PMID 27956542›Full record

GuidelineJournal of the National Comprehensive Cancer Network : JNCCN2016

Myeloproliferative Neoplasms, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.

Ruben Mesa, Catriona Jamieson, Ravi Bhatia, Michael W Deininger, Aaron T Gerds, Ivana Gojo, Jason Gotlib, Krishna Gundabolu, Gabriela Hobbs, Rebecca B Klisovic and 17 more

Open access · bronzeAbstract readPractice Guideline
In one paragraph

Guideline in Journal of the National Comprehensive Cancer Network : JNCCN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Patient Perspectives Regarding Allogeneic Bone Marrow Transplantation in Myelofibrosis.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019
    Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Disease Modification in Myelofibrosis: An Elusive Goal?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Investigation and management of erythrocytosis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020
    Review
  15. Review
  16. Article
  17. Review
  18. Observational
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 1 institution in 1 country.

Ruben Mesa
Catriona Jamieson
Ravi Bhatia
Michael W Deininger
Aaron T Gerds
Ivana Gojo
Jason Gotlib
Krishna Gundabolu
Gabriela Hobbs
Rebecca B Klisovic
Patricia Kropf
Sanjay R Mohan
Stephen Oh
Eric Padron
Nikolai Podoltsev
Daniel A Pollyea
Raajit Rampal
Lindsay A M Rein
Bart Scott
David S Snyder
Brady L Stein
Srdan Verstovsek
Martha Wadleigh
Eunice S Wang
Mary Anne Bergman
Kristina M Gregory
Hema Sundar
Sidney Kimmel Comprehensive Cancer Center · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Genomic profiling and development of murine models of transformation of MPNsK08CA188529 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI RAMPAL, RAAJIT · 2014 to 2018
$891k
NCI NIH HHS K08 CA188529NCI NIH HHS P30 CA012197
6 · The paper itself

Abstract

Myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET) are a group of heterogeneous disorders of the hematopoietic system collectively known as Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). The diagnosis and the management of patients with MPNs have evolved since the identification of mutations that activate the JAK pathway (JAK2, CALR, and MPL mutations) and the development of targeted therapies has resulted in significant improvements in disease-related symptoms and quality of life. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnostic workup of MPN (MF, PV, and ET), risk stratification, treatment, and supportive care strategies for the management of MF.

Indexed as

Polycythemia VeraPrimary MyelofibrosisThrombocythemia, EssentialCalreticulinHumansJanus Kinase 2Medical OncologyMutationPhiladelphia ChromosomePrevalenceQuality of LifeReceptors, ThrombopoietinRisk AssessmentSignal TransductionCalreticulinCALR protein, humanJAK2 protein, humanJanus Kinase 2MPL protein, humanReceptors, Thrombopoietin

Identifiers

PMID27956542
PMCPMC11807340
OpenAlexW2570291199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.