ArticleJournal of immunology (Baltimore, Md. : 1950)2017
Cutting Edge: Helminth Coinfection Blocks Effector Differentiation of CD8 T Cells through Alternate Host Th2- and IL-10-Mediated Responses.
Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- In vivo reduction of Treg expansion in rodent helminth-malaria coinfection.Parasites & vectors · 2026Article
- Pan-cancer screening, bioinformatics analysis, and experimental validation identify TEX10 as a key biomarker driving OSCC progression.Frontiers in genetics · 2026Article
- Article
- Immunomodulatory effects of chronic trichinellosis onPathogens and global health · 2023Article
- Distinct T helper cell-mediated antitumor immunity: T helper 2 cells in focus.Cancer pathogenesis and therapy · 2023Review
- The Impact of Helminth Coinfection on Innate and Adaptive Immune Resistance and Disease Tolerance during Toxoplasmosis.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections.Cell · 2021Article
- The Anti-Inflammatory Immune Response in EarlyJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner.Journal of neuroinflammation · 2019Article
- Helminth-induced IL-4 expands bystander memory CD8Nature communications · 2018Article
- The impact of a helminth-modified microbiome on host immunity.Mucosal immunology · 2018Review
- A Role for Epitope Networking in Immunomodulation by Helminths.Frontiers in immunology · 2018Article
- Helminth Infections Induce Tissue Tolerance Mitigating Immunopathology but Enhancing Microbial Pathogen Susceptibility.Frontiers in immunology · 2018Review
- The Influence of Parasite Infections on Host Immunity to Co-infection With Other Pathogens.Frontiers in immunology · 2018Review
- Susceptibility of dendritic cells from individuals with schistosomiasis to infection by Leishmania braziliensis.Molecular immunology · 2018Article
- Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.Frontiers in cellular and infection microbiology · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
Concurrent helminth infection potently inhibits T cell immunity; however, whether helminthes prevent T cell priming or skew clonal recruitment and effector differentiation is not known. Using coinfection with two natural mouse pathogens, Heligmosomoides polygyrus and Toxoplasma gondii, to investigate the negative impact of helminthes on the CD8 T cell response, we demonstrate helminth-induced suppression of IL-12-dependent differentiation of killer-like receptor G1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.