Evidence map›Paper›PMID 27956473›Full record

ArticleThe Journal of general physiology2017

Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the KATP channel.

Maria S Remedi, Jonathan B Friedman, Colin G Nichols

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Gain-of-Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Article
  4. PDX1Nature communications · 2021
    Article
  5. Article
  6. Article
  7. The role of KActa pharmacologica Sinica · 2018
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maria S RemediDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110 mremedi@wustl.edu.ORCID http://orcid.org/0000-0003-2048-472X
Jonathan B FriedmanDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110.
Colin G NicholsDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110.
Washington University in St. Louis · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1M
BETA-CELL EXHAUSTION AND GLUCOTOXICITY IN DIABETESR01DK098584 · NIDDK · WASHINGTON UNIVERSITY · PI REMEDI, MARIA SARA · 2013 to 2017
$1.7M
ELECTRICAL CONTROL OF INSULIN SECRETIONR01DK109407 · NIDDK · WASHINGTON UNIVERSITY · PI NICHOLS, COLIN G · 2016 to 2019
$1.4M
Beta-Cell Exhaustion and Glucotoxicity in DiabetesR56DK098584 · NIDDK · WASHINGTON UNIVERSITY · PI REMEDI, MARIA SARA · 2019 to 2019
$117k
NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK098584NIDDK NIH HHS R01 DK109407NIDDK NIH HHS R56 DK098584
6 · The paper itself

Abstract

Gain-of-function (GOF) mutations in the pore-forming (Kir6.2) and regulatory (SUR1) subunits of K

Indexed as

MutationAnimalsDiabetes MellitusHumansInsulinInsulin-Secreting CellsIslets of LangerhansKATP ChannelsMiceMice, TransgenicInsulinKATP ChannelsuK-ATP-1 potassium channel

Identifiers

PMID27956473
PMCPMC5217086
OpenAlexW2562365380

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.