ReviewClinical medicine (London, England)2016
Towards understanding and managing chronic cough.
Review in Clinical medicine (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- The P2X3 receptor antagonist filapixant in patients with refractory chronic cough: a randomized controlled trial.Respiratory research · 2023Trial
- Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study.The European respiratory journal · 2021Trial
- Article
- Unraveling the neuro-immune axis in cough hypersensitivity: from pathogenesis to synergistic management.Frontiers in medicine · 2026Review
- Automated Cough Analysis with Convolutional Recurrent Neural Network.Bioengineering (Basel, Switzerland) · 2024Article
- Exploring the concept of disease control in chronic cough.ERJ open research · 2024Article
- The "vicious circle" of chronic cough: the patient experience - qualitative synthesis.ERJ open research · 2023Review
- Neural control of the lower airways: Role in cough and airway inflammatory disease.Handbook of clinical neurology · 2022Review
- Long-Term Outcomes of Chronic Cough Reduction after Laparoscopic Nissen Fundoplication-A Single-Center Study.Medicina (Kaunas, Lithuania) · 2021Article
- Management of intractable chronic cough during awake craniotomy: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Chronic cough caused by choledochoduodenal fistula: a case report.BMC pulmonary medicine · 2021Article
- Prevalence, incidence and characteristics of chronic cough among adults from the Canadian Longitudinal Study on Aging.ERJ open research · 2021Article
- Intra-Arterial, but Not Intrathecal, Baclofen and Codeine Attenuates Cough in the Cat.Frontiers in physiology · 2021Article
- Cough as an adverse effect on inhalation pharmaceutical products.British journal of pharmacology · 2020Review
- Obesity Predicts Treatment Response to Proton Pump Inhibitor Therapy in Patients with Chronic Cough.Lung · 2020Observational
- Change in the symptom profile treated as asthma - two cross-sectional studies twenty years apart.Respiratory research · 2020Article
- Inhibition of viral and bacterial trigger-stimulated prostaglandin ESAGE open medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic cough is a common and troublesome condition affecting approximately 12% of the general population. It is associated with poor quality of life with psychological, social and physical consequences. Patients typically complain of a dry irritating cough, driven by a strong urge to cough associated with a sensation or irritation located in the throat. Treatment of potential 'causes', ie asthma, gastro-oesophageal reflux disease and rhino-sinusitis, may produce a complete or partial response, but the response of some patients to opiates and alpha-2-delta ligand antagonists (gabapentin and pregabalin) supports the concept that this is primarily a neurological disorder, characterised by hyper-responsiveness of the nerves. Novel and highly effective neuronal treatments are in development and offer hope of better symptom control with fewer side effects within a few years. This review focuses on understanding the mechanism of chronic cough, current management approaches and research that may lead to novel therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.