Evidence map›Paper›PMID 27956425›Full record

ArticleAntimicrobial agents and chemotherapy2017

Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of β-Lactamase-Producing Escherichia coli.

Kristin R Baker, Helga Høeg Sigurðardóttir, Bimal Jana, Luca Guardabassi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kristin R BakerDepartment of Veterinary Disease Biology, University of Copenhagen, Frederiksberg, Denmark KrBaker@rossvet.edu.kn BJana@rossvet.edu.kn LGuardabassi@rossvet.edu.kn.
Helga Høeg SigurðardóttirDepartment of Veterinary Disease Biology, University of Copenhagen, Frederiksberg, Denmark.
Bimal JanaDepartment of Veterinary Disease Biology, University of Copenhagen, Frederiksberg, Denmark KrBaker@rossvet.edu.kn BJana@rossvet.edu.kn LGuardabassi@rossvet.edu.kn.
Luca GuardabassiDepartment of Veterinary Disease Biology, University of Copenhagen, Frederiksberg, Denmark KrBaker@rossvet.edu.kn BJana@rossvet.edu.kn LGuardabassi@rossvet.edu.kn.
Ross University School of Veterinary Medicine · KNUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reversal of antimicrobial resistance is an appealing and largely unexplored strategy in drug discovery. The objective of this study was to identify potential targets for "helper" drugs reversing cephem resistance in

Indexed as

Gene Expression Regulation, BacterialGene SilencingAnti-Bacterial Agentsbeta-Lactamasesbeta-Lactam ResistanceCell WallCephalosporinsConjugation, GeneticEscherichia coliEscherichia coli ProteinsMicrobial Sensitivity TestsPenicillin-Binding ProteinsPeptidoglycan GlycosyltransferasePlasmidsSerine-Type D-Ala-D-Ala CarboxypeptidaseAnti-Bacterial Agentsbeta-lactamase CMY-2, E colibeta-lactamase CTX-M-15beta-Lactamasesbeta-lactamase TEM-3CephalosporinsEscherichia coli Proteinspenicillin-binding protein 1B, E coliPenicillin-Binding ProteinsPeptidoglycan GlycosyltransferaseSerine-Type D-Ala-D-Ala Carboxypeptidasecephem resistanceextended-spectrum β-lactamase (ESBL)helper drug

Identifiers

PMID27956425
PMCPMC5328576
OpenAlexW2562264420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.