Evidence map›Paper›PMID 27956398›Full record

Trial reportJournal of the American Heart Association2016

Neurohormonal Activation After Atrial Fibrillation Initiation in Patients Eligible for Catheter Ablation: A Randomized Controlled Study.

Emmanouil Charitakis, Håkan Walfridsson, Eva Nylander, Urban Alehagen

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01553045 (Observational Study of the Variation in Health-related Quality of Life and Symptom Burden in Patients Accepted for Catheter Ablation of Atrial Fibrillation in Relation to Biomarkers, Intracardiac Pressures and Echocardiography.), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01553045 unknown statusnot on this map

Observational Study of the Variation in Health-related Quality of Life and Symptom Burden in Patients Accepted for Catheter Ablation of Atrial Fibrillation in Relation to Biomarkers, Intracardiac Pressures and Echocardiography.

TypeobservationalSponsorUniversity Hospital, LinkoepingRan2011 to 2015Enrolled200ConditionsArrhythmias, Cardiac, Heart Failure, Systolic, Atrial Fibrillation
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Observational
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Emmanouil CharitakisDepartment of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden mcharitakis@gmail.com.
Håkan WalfridssonDepartment of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Eva NylanderDepartment of Clinical Physiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Urban AlehagenDepartment of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Linköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiomarker activation in atrial fibrillation (AF) has been widely studied, but the immediate effect of AF initiation remains unclear. We studied the effect of AF initiation on 2 cardiac biomarkers: the N-terminal fragment of the proB-type natriuretic peptide (NT-proBNP), the midregional fragment of the N-terminal of pro-atrial natriuretic peptide (MR-proANP), and 2 extracardiac biomarkers-the copeptin and the midregional portion of proadrenomedullin (MR-proADM). METHODS AND

resultsThis was a randomized controlled study, including 45 patients with AF who had been referred for radiofrequency ablation to the University Hospital, Linköping, Sweden, between February 2012 and April 2014. Freedom from AF during the 4 days prior to radiofrequency ablation was confirmed by transtelephonic ECGs. Biomarkers were collected from the femoral vein (fv), coronary sinus (CS), and left atrium (LA) prior to AF initiation (baseline) and 30 minutes later. The MR-proANP and NT-proBNP concentrations increased in the intervention group compared with the control group 30 minutes after the initiation of AF (MR-proANP: P

conclusionsAF is a strong stimulus that results in immediate activation of different biomarkers. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01553045.

Indexed as

Catheter AblationAnalysis of VarianceAtrial FibrillationAtrial Natriuretic FactorBiomarkersFemaleFluoroscopyGlycopeptidesHumansMaleMiddle AgedNatriuretic Peptide, BrainOperative TimePeptide FragmentsAtrial Natriuretic FactorBiomarkerscopeptinsGlycopeptidesmidregional pro-atrial natriuretic peptide, humanNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)atrial fibrillationbiomarkersradiofrequency ablation

Identifiers

PMID27956398
PMCPMC5210434
OpenAlexW2565764692

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.