Evidence map›Paper›PMID 27956135›Full record

ArticleAntiviral research2017

Effects of ribavirin/sofosbuvir treatment and ITPA phenotype on endogenous purines.

Leah C Jimmerson, Carolyn W Clayton, Samantha MaWhinney, Eric G Meissner, Zayani Sims, Shyamasundaran Kottilil, Jennifer J Kiser

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antiviral research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Leah C JimmersonUniversity of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences Aurora, CO, USA.
Carolyn W ClaytonUniversity of Colorado, School of Public Health Aurora, CO, USA.
Samantha MaWhinneyUniversity of Colorado, School of Public Health Aurora, CO, USA.
Eric G MeissnerCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Zayani SimsCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Shyamasundaran KottililCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Jennifer J KiserUniversity of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences Aurora, CO, USA. Electronic address: Jennifer.kiser@ucdenver.edu.
National Institutes of Health Clinical Center · USColorado School of Public Health · USUniversity of Montana · US

Funding

LOC-IMPAACT Leadership GroupPharmacokinetics and Safety of Remdesivir for Treatment of COVID-19 in Pregnant Women in the USUM1AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI Jennifer Jao, Sharon A Nachman · 2011 to 2026
$278.1M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
Ribavirin depletes endogenous nucleotide poolsR03DK096121 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI KISER, JENNIFER JUSTICE · 2012 to 2013
$162k
DC Partnership for HIV/AIDS Progress (DC PFAP)ZIACL009010 · CLC · CLINICAL CENTER · PI MASUR, HENRY · 2010 to 2025
$0k
Analysis of Stored Samples Collected Using Previously Expired ProtocolsZIACL009021 · CLC · CLINICAL CENTER · PI MASUR, HENRY · 2015 to 2024
$0k
Intramural NIH HHS ZIA CL009010NCRR NIH HHS UL1 RR025780NIAID NIH HHS UM1 AI068632NIDDK NIH HHS R03 DK096121
6 · The paper itself

Abstract

Ribavirin (RBV), a purine analog, causes hemolytic anemia in some patients. In vitro, anemia appears to result from depletion of endogenous purines, but there are limited data in vivo. Single nucleotide polymorphisms in the gene encoding the inosine triphosphatase (ITPA) enzyme have been associated with protection against RBV-induced anemia and may mediate the effect of RBV treatment on endogenous purines. The purpose of this work was to determine the effect of RBV treatment on endogenous purine concentrations in individuals being treated for chronic hepatitis C virus (HCV) infection. Adenosine triphosphate (ATP), guanosine triphosphate (GTP), inosine triphosphate (ITP) and ribavirin triphosphate (RTP) were measured in whole blood obtained from 47 HCV-infected individuals at day zero (baseline), day three, day 28 and day 84 of RBV/sofosbuvir (SOF) treatment. ATP decreased -35.1% and -38.6% (p < 0.0001) at day 28 and day 84 of treatment, respectively compared to baseline. The decrease in ATP was greater in patients with ≤60% ITPA activity compared to those with 100% ITPA activity (-29.4% vs. -9.6%). GTP did not change during treatment but was 16.5% (p = 0.01) higher per 100 pmol/10

Indexed as

Adenosine TriphosphateAnemia, HemolyticFemaleGuanosine TriphosphateHepatitis C, ChronicHumansInosine TriphosphataseInosine TriphosphateMaleMiddle AgedNucleotidesPhenotypePolymorphism, Single NucleotidePurinesPyrophosphatasesRetrospective StudiesAdenosine TriphosphateGuanosine TriphosphateInosine TriphosphataseInosine TriphosphateNucleotidesPurinesPyrophosphatasesRibavirinribavirin 5'-triphosphateSofosbuvirAdenosine triphosphateAnemiaGuanosine triphosphateInosine triphosphateITPA activityRibavirin triphosphate

Identifiers

PMID27956135
PMCPMC10837792
OpenAlexW2560266656

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.