Evidence map›Paper›PMID 27956055›Full record

ArticleNeuropharmacology2017

Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct α

Christopher Cottingham, Pulin Che, Wei Zhang, Hongxia Wang, Raymond X Wang, Stefanie Percival, Tana Birky, Lufang Zhou, Kai Jiao, Qin Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Molecular Features Triggered by Antipsychotic Medication in Brain Cells.Advances in experimental medicine and biology · 2022
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Christopher CottinghamDepartment of Cell, Molecular and Developmental Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Department of Biology and Chemistry, Morehead State University, Morehead, KY 40351, USA.
Pulin CheDepartment of Cell, Molecular and Developmental Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Wei ZhangSouthern Research Institute, Birmingham, AL 35205, USA.
Hongxia WangDepartment of Cell, Molecular and Developmental Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Raymond X WangDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Stefanie PercivalDepartment of Cell, Molecular and Developmental Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Tana BirkyDepartment of Cell, Molecular and Developmental Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Lufang ZhouDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Kai JiaoDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Qin WangDepartment of Cell, Molecular and Developmental Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: qinwang@uab.edu.
University of Alabama at Birmingham · USSouthern Research Institute · US

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
Regulation of novel alpha2A adrenergic receptor signaling by spinophilinR01MH081917 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WANG, QIN · 2009 to 2019
$3.9M
Mitochondria-SR Redox Signaling and Ca2+ Handling in Healthy and Failing HeartsR01HL121206 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHOU, LUFANG · 2015 to 2019
$1.8M
NHLBI NIH HHS R01 HL121206NIGMS NIH HHS P20 GM103436NIMH NIH HHS R01 MH081917
6 · The paper itself

Abstract

The therapeutic mechanism of action underlying many psychopharmacological agents remains poorly understood, due largely to the extreme molecular promiscuity exhibited by these agents with respect to potential central nervous system targets. Agents of the tricyclic chemical class, including both antidepressants and antipsychotics, exhibit a particularly high degree of molecular promiscuity; therefore, any clarification of how these agents interact with specific central nervous system targets is of great potential significance to the field. Here, we present evidence demonstrating that tricyclic antipsychotics appear to segregate into three distinct groups based upon their molecular interactions with the centrally-important α

Indexed as

AnimalsAntipsychotic Agentsbeta-Arrestin 1beta-Arrestin 2Caveolin 1ChlorpromazineClozapineCyclic AMPEndocytosisFibroblastsFluphenazineGuanosine 5'-O-(3-Thiotriphosphate)HEK293 CellsHumansMAP Kinase Signaling SystemMiceAntipsychotic Agentsbeta-Arrestin 1beta-Arrestin 2Caveolin 1ChlorpromazineClozapineCyclic AMPFluphenazineGuanosine 5'-O-(3-Thiotriphosphate)NorepinephrineReceptors, Adrenergic, alpha-2AntipsychoticArrestinBiased agonismEndocytosisLipid raftα(2) adrenergic receptor

Identifiers

PMID27956055
PMCPMC5385157
OpenAlexW2560665711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.