ArticleDevelopmental biology2017
Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart field.
Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 49 citations in OpenAlex.
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- Duplicated Cervical Internal Carotid Artery with Ipsilateral Persistent Stapedial Artery and Contralateral Aberrant Internal Carotid Artery: A Case Report.Journal of neuroendovascular therapy · 2025Article
- Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease.Circulation research · 2024Article
- Endothelial gene regulatory elements associated with cardiopharyngeal lineage differentiation.Communications biology · 2024Article
- Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.Developmental biology · 2024Article
- SMAD4: A critical regulator of cardiac neural crest cell fate and vascular smooth muscle development.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Development Features on the Selection of Animal Models for Teratogenic Testing.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Human Cardiac Development.Advances in experimental medicine and biology · 2024Article
- Tmem88 confines ectodermal Wnt2bb signaling in pharyngeal arch artery progenitors for balancing cell cycle progression and cell fate decision.Nature cardiovascular research · 2023Article
- Chemokine signaling synchronizes angioblast proliferation and differentiation during pharyngeal arch artery vasculogenesis.Development (Cambridge, England) · 2022Article
- New Insights into the Diversity of Branchiomeric Muscle Development: Genetic Programs and Differentiation.Biology · 2022Review
- Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals.Cell research · 2022Article
- Integration of vascular progenitors into functional blood vessels represents a distinct mechanism of vascular growth.Developmental cell · 2022Article
- A pictorial account of the human embryonic heart between 3.5 and 8 weeks of development.Communications biology · 2022Article
- Whole-Mount Immunofluorescence Protocol for 3D Imaging, Reconstruction, and Quantification of Fourth Pharyngeal Arch Artery Formation.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Endothelial cells during craniofacial development: Populating and patterning the head.Frontiers in bioengineering and biotechnology · 2022Review
- Fetal Blood Flow and Genetic Mutations in Conotruncal Congenital Heart Disease.Journal of cardiovascular development and disease · 2021Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Oxygenated blood from the heart is directed into the systemic circulation through the aortic arch arteries (AAAs). The AAAs arise by remodeling of three symmetrical pairs of pharyngeal arch arteries (PAAs), which connect the heart with the paired dorsal aortae at mid-gestation. Aberrant PAA formation results in defects frequently observed in patients with lethal congenital heart disease. How the PAAs form in mammals is not understood. The work presented in this manuscript shows that the second heart field (SHF) is the major source of progenitors giving rise to the endothelium of the pharyngeal arches 3 - 6, while the endothelium in the pharyngeal arches 1 and 2 is derived from a different source. During the formation of the PAAs 3 - 6, endothelial progenitors in the SHF extend cellular processes toward the pharyngeal endoderm, migrate from the SHF and assemble into a uniform vascular plexus. This plexus then undergoes remodeling, whereby plexus endothelial cells coalesce into a large PAA in each pharyngeal arch. Taken together, our studies establish a platform for investigating cellular and molecular mechanisms regulating PAA formation and alterations that lead to disease.
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