ArticleBMC medicine2016
Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence.
Article in BMC medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
103 citing papers in PubMed, 3 syntheses or guidelines pooled it, 219 citations in OpenAlex.
- Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study.BMC medicine · 2024Pooled it
- Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study.BMC medicine · 2023Pooled it
- Pooled it
- Early ascending growth is associated with maternal lipoprotein profile during mid and late pregnancy and in cord blood.International journal of obesity (2005) · 2023Trial
- Do nuclear magnetic resonance (NMR)-based metabolomics improve the prediction of pregnancy-related disorders? Findings from a UK birth cohort with independent validation.BMC medicine · 2020Trial
- Metformin and insulin treatment of gestational diabetes: effects on inflammatory markers and IGF-binding protein-1 - secondary analysis of a randomized controlled trial.BMC pregnancy and childbirth · 2020Trial
- Differences in First-Trimester Maternal Metabolomic Profiles in Pregnancies Conceived From Fertility Treatments.The Journal of clinical endocrinology and metabolism · 2019Trial
- Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection.Scientific reports · 2019Trial
- Trial
- The plasma metabolome of women in early pregnancy differs from that of non-pregnant women.PloS one · 2019Trial
- Lipidomic signatures in gestational diabetes mellitus and postpartum type 2 diabetes mellitus: a narrative review of etiologic and predictive implications.EBioMedicine · 2026Review
- Impacts of maternal lipid and homocysteine levels on the risks of pregnancy complications and adverse outcomes in both singleton and twin pregnancies: a population-based observational cohort study.BMC pregnancy and childbirth · 2026Observational
- Associations between maternal prepregnancy body mass index and maternal and cord blood metabolome.Journal of the Endocrine Society · 2026Article
- Cardiovascular complications of pregnancy.The Journal of clinical investigation · 2026Review
- NMR-based clinical metabolomics for predictive screening of gestational diabetes mellitus (GDM) during the first trimester: a pilot study on North Indian population.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Role of Lipoprotein(a) in Atherosclerotic Cardiovascular Disease in South Asian Individuals.Journal of the American Heart Association · 2025Review
- Exposure to Extreme Heat Increases Preterm Birth Risk: Hypothetical Pathophysiological Mechanisms.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Physiological and Microbial Community Dynamics in Does During Mid-Gestation to Lactation and Their Impact on the Growth, Immune Function, and Microbiome Transmission of Offspring Kids.Animals : an open access journal from MDPI · 2025Article
- Higher prenatal dietary glycemic index in the third trimester of pregnancy is associated with infant negative affect at 6 months.Scientific reports · 2025Article
- Maternal iron deficiency assessed by serum ferritin and birth outcomes in mainland China.Scientific reports · 2025Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 13 institutions in 5 countries.
Funding
Abstract
backgroundPregnancy triggers well-known alterations in maternal glucose and lipid balance but its overall effects on systemic metabolism remain incompletely understood.
methodsDetailed molecular profiles (87 metabolic measures and 37 cytokines) were measured for up to 4260 women (24-49 years, 322 pregnant) from three population-based cohorts in Finland. Circulating molecular concentrations in pregnant women were compared to those in non-pregnant women. Metabolic profiles were also reassessed for 583 women 6 years later to uncover the longitudinal metabolic changes in response to change in the pregnancy status.
resultsCompared to non-pregnant women, all lipoprotein subclasses and lipids were markedly increased in pregnant women. The most pronounced differences were observed for the intermediate-density, low-density and high-density lipoprotein triglyceride concentrations. Large differences were also seen for many fatty acids and amino acids. Pregnant women also had higher concentrations of low-grade inflammatory marker glycoprotein acetyls, higher concentrations of interleukin-18 and lower concentrations of interleukin-12p70. The changes in metabolic concentrations for women who were not pregnant at baseline but pregnant 6 years later (or vice versa) matched (or were mirror-images of) the cross-sectional association pattern. Cross-sectional results were consistent across the three cohorts and similar longitudinal changes were seen for 653 women in 4-year and 497 women in 10-year follow-up. For multiple metabolic measures, the changes increased in magnitude across the three trimesters.
conclusionsPregnancy initiates substantial metabolic and inflammatory changes in the mothers. Comprehensive characterisation of normal pregnancy is important for gaining understanding of the key nutrients for fetal growth and development. These findings also provide a valuable molecular reference in relation to studies of adverse pregnancy outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.