Evidence map›Paper›PMID 27955697›Full record

SynthesisGenome biology2016

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.

Symen Ligthart, Carola Marzi, Stella Aslibekyan, Michael M Mendelson, Karen N Conneely, Toshiko Tanaka, Elena Colicino, Lindsay L Waite, Roby Joehanes, Weihua Guan and 79 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Genome biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 226 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 18 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 18 syntheses or guidelines pooled it, 331 citations in OpenAlex.

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  19. Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Trial
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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

89 authors at 20 institutions in 6 countries.

Symen LigthartDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Carola MarziInstitute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherber, Germany.
Stella AslibekyanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Michael M MendelsonBoston University School of Medicine, Boston, MA, USA.
Karen N ConneelyDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Elena ColicinoDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Lindsay L WaiteHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Roby JoehanesHebrew SeniorLife, Harvard Medical School, Boston, MA, USA.
Weihua GuanDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Cathy ElksMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Riccardo MarioniCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Min A JhunDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Golareh AghaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Jan BresslerHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Cavin K Ward-CavinessInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherber, Germany.
Brian H ChenLongitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Tianxiao HuanPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Kelly BakulskiCenter for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Elias L SalfatiDepartment of Medicine - Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
WHI-EMPC Investigators
Giovanni FioritoHuman Genetics Foundation, Torino, Italy.
CHARGE epigenetics of Coronary Heart Disease
Simone WahlInstitute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherber, Germany.
Katharina SchrammInstitute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Jin ShaDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Dena G HernandezLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Allan C JustDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Nona SotoodehniaCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Luke C PillingEpidemiology and Public Health, University of Exeter Medical School, RILD Building Level 3 Research, Exeter, UK.
James S PankowDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Phil S TsaoStanford University School of Medicine, Palo Alto, CA, USA.
Chunyu LiuPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Simonetta GuarreraHuman Genetics Foundation, Torino, Italy.
Vasiliki J MichopoulosDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Alicia K SmithDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Marjolein J PetersDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
David MelzerEpidemiology and Public Health, University of Exeter Medical School, RILD Building Level 3 Research, Exeter, UK.
Pantel VokonasVA Boston Healthcare System and Boston University Schools of Public Health and Medicine, Jamaica Plain, Boston, MA, USA.
Myriam FornageHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Holger ProkischInstitute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Audrey Y ChuPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Christian HerderInstitute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Harald GrallertInstitute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherber, Germany.
Chen YaoPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Sonia ShahQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Allan F McRaeQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Honghuang LinDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Steve HorvathUCLA, Department of Human Genetics, Gonda Research Center, David Geffen School of Medicine, Los Angeles, CA, USA.
Daniele FallinCenter for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Andrew P FeinbergCenter for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Peter M VisscherCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Joanne M MurabitoBoston University School of Medicine, Boston, MA, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Devin M AbsherHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Elisabeth B BinderDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Andrew B SingletonLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherber, Germany.
Melanie WaldenbergerInstitute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherber, Germany.
Giuseppe MatulloHuman Genetics Foundation, Torino, Italy.
Joel D SchwartzDepartment of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Ellen W DemerathDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
André G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Joyce B J van MeursDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Yii-Der Ida ChenDepartment of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
Daniel LevyBoston University School of Medicine, Boston, MA, USA.
Stephen T TurnerDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Kerry J ResslerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Ken K OngMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Wolfgang KoenigDepartment of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.
Donna K ArnettUniversity of Kentucky, College of Public Health, Lexington, KY, USA.
Andrea A BaccarelliDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Emelia J BenjaminBoston University School of Medicine, Boston, MA, USA.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. a.dehghan@erasmusmc.nl.
Harvard University · USNational Institutes of Health · USBoston University · USEmory University · USHelmholtz Zentrum München · DEErasmus MC · NLTranslational Research Institute · AUUniversity of Minnesota · USJohns Hopkins University · USNational Institute on Aging · USUniversity of Washington · USBoston Children's Hospital · USInstitute of Genetics and Cancer · GBMayo Clinic · USPalo Alto University · USUniversity of Cambridge · GBUniversity of Exeter · GBUniversity of Michigan · USHudsonAlpha Institute for Biotechnology · USThe University of Queensland · AU

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Building on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2014 to 2026
$21.3M
X LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 1985 to 2007
$21.3M
Research Training and Education Core (Core D) P50HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2013 to 2017
$20.1M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Genetic and Trauma-Related Risk Factors for PTSDR01MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2005 to 2014
$8.5M
T32 Training Program in Mechanisms and Innovation in Vascular DiseaseT32HL098049 · NHLBI · STANFORD UNIVERSITY · PI Nicholas James Leeper, Philip S Tsao · 2010 to 2026
$6.3M
ARRA NIH HHSCancer Research UK C864/A8257Medical Research Council G0401527Medical Research Council G9502233Medical Research Council MC_EX_MR/L100002/1Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MR/L00002/1Medical Research Council MR/M023095/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000454NCRR NIH HHS M01 RR000039NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS P50 HL120163NHLBI NIH HHS R01 HL076784NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL092111NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL104135NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111089NHLBI NIH HHS R01 HL116747NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL133221NHLBI NIH HHS RC1 HL100185NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS T32 HL098049NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U10 HL054457NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG028321NIA NIH HHS R01 AG042187NIA NIH HHS R01 AG045255NIDDK NIH HHS P30 DK063491NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES023450NIEHS NIH HHS R01 ES015172NIEHS NIH HHS R01 ES021733NIMH NIH HHS R01 MH071537NIMH NIH HHS R01 MH096764NIMH NIH HHS R56 MH071537
6 · The paper itself

Abstract

backgroundChronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation.

resultsWe performed a meta-analysis of epigenome-wide association studies (EWAS) of serum C-reactive protein (CRP), which is a sensitive marker of low-grade inflammation, in a large European population (n = 8863) and trans-ethnic replication in African Americans (n = 4111). We found differential methylation at 218 CpG sites to be associated with CRP (P < 1.15 × 10

conclusionWe have completed an EWAS of chronic low-grade inflammation and identified many novel genetic loci underlying inflammation that may serve as targets for the development of novel therapeutic interventions for inflammation.

Indexed as

Epigenesis, GeneticBlack or African AmericanCpG IslandsC-Reactive ProteinDNA MethylationFemaleGene ExpressionGenetic VariationGenome-Wide Association StudyHumansInflammationMaleNucleotide MotifsQuantitative Trait LociWhite PeopleC-Reactive ProteinBody mass indexCoronary heart diseaseC-reactive proteinDiabetesDNA methylationEpigenome-wide association studyInflammation

Identifiers

PMID27955697
PMCPMC5151130
OpenAlexW2562655012

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.