Evidence map›Paper›PMID 27955627›Full record

ArticleBMC infectious diseases2016

A longitudinal cohort study of HIV 'treatment as prevention' in gay, bisexual and other men who have sex with men: the Treatment with Antiretrovirals and their Impact on Positive And Negative men (TAIPAN) study protocol.

D Callander, M Stoové, A Carr, J F Hoy, K Petoumenos, M Hellard, J Elliot, D J Templeton, S Liaw, D P Wilson and 16 more

Open access · goldAbstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

1.1field-weighted citation impact, top 21% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

Leaving No One Behind: Human Rights and Gender as Critical Frameworks for U=U.Health and human rights · 2022
Review
Monitoring the Control of Sexually Transmissible Infections and Blood-Borne Viruses: Protocol for the Australian Collaboration for Coordinated Enhanced Sentinel Surveillance (ACCESS).JMIR research protocols · 2018
Article
The 2016 HIV diagnosis and care cascade in New South Wales, Australia: meeting the UNAIDS 90-90-90 targets.Journal of the International AIDS Society · 2018
Article
Expanded HIV pre-exposure prophylaxis (PrEP) implementation in communities in New South Wales, Australia (EPIC-NSW): design of an open label, single arm implementation trial.BMC public health · 2018
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 10 institutions in 1 country.

D CallanderThe Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0002-4116-4250

M StoovéBurnet Institute, Melbourne, VIC, Australia.

A CarrSt Vincent's Hospital, Sydney, NSW, Australia.

J F HoyMonash University, Melbourne, VIC, Australia.

K PetoumenosThe Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney, NSW, 2052, Australia.

M HellardBurnet Institute, Melbourne, VIC, Australia.

J ElliotMonash University, Melbourne, VIC, Australia.

D J TempletonThe Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney, NSW, 2052, Australia.

S LiawSchool of Public Health and Community Medicine, UNSW Australia, Sydney, NSW, Australia.

D P WilsonBurnet Institute, Melbourne, VIC, Australia.

A GrulichThe Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney, NSW, 2052, Australia.

D A CooperThe Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney, NSW, 2052, Australia.

A PedranaMonash University, Melbourne, VIC, Australia.

B DonovanThe Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney, NSW, 2052, Australia.

J McMahonMonash University, Melbourne, VIC, Australia.

G PrestageThe Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney, NSW, 2052, Australia.

M HoltCentre for Social Research in Health, UNSW Australia, Sydney, NSW, Australia.

C K FairleyMonash University, Melbourne, VIC, Australia.

N McKellar-StewartACON Northern Rivers, Lismore, NSW, Australia.

S RuthVictorian AIDS Council, Melbourne, VIC, Australia.

J AsselinBurnet Institute, Melbourne, VIC, Australia.

P KeenThe Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney, NSW, 2052, Australia.

C CooperPositiveLife New South Wales, Sydney, NSW, Australia.

B AllanLiving Positive Victoria, Melbourne, VIC, Australia.

J M KaldorThe Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney, NSW, 2052, Australia.

R GuyThe Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney, NSW, 2052, Australia. rguy@kirby.unsw.edu.au.

Burnet Institute · AUThe Alfred Hospital · AUUNSW Sydney · AUCancer Council Victoria · AULa Trobe University · AUMelbourne Sexual Health Centre · AUMonash University · AUSt Vincent's Hospital Sydney · AUSydney Hospital · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAustralia has increased coverage of antiretroviral treatment (ART) over the past decade, reaching 73% uptake in 2014. While ART reduces AIDS-related deaths, accumulating evidence suggests that it could also bolster prevention efforts by reducing the risk of HIV transmission ('treatment as prevention'). While promising, evidence of community-level impact of treatment as prevention on reducing HIV incidence among gay and bisexual men is limited. We describe a study protocol that aims to determine if scale up of testing and treatment for HIV leads to a reduction in community viraemia and, in turn, if this reduction is temporally associated with a reduction in HIV incidence among gay and bisexual men in Australia's two most populous states.

methodsOver the period 2009 to 2017, we will establish two cohorts making use of clinical and laboratory data electronically extracted retrospectively and prospectively from 73 health services and laboratories in the states of New South Wales and Victoria. The 'positive cohort' will consist of approximately 13,000 gay and bisexual men (>90% of all people living with HIV). The 'negative cohort' will consist of at least 40,000 HIV-negative gay and bisexual men (approximately half of the total population). Within the negative cohort we will use standard repeat-testing methods to calculate annual HIV incidence. Community prevalence of viraemia will be defined as the proportion of men with a viral load ≥200RNA copies/mm DISCUSSION: This study will provide important information on whether 'treatment as prevention' is associated with a reduction in HIV incidence at a community level among gay and bisexual men.

Indexed as

AdultAnti-HIV AgentsAustraliaBisexualityCohort StudiesHIVHIV InfectionsHomosexuality, MaleHumansLongitudinal StudiesMalePrevalenceRetrospective StudiesRNA, ViralViral LoadAnti-HIV AgentsRNA, ViralCohortGay menHIVTreatment as prevention

Identifiers

PMID27955627

DOI10.1186/s12879-016-2073-2

PMCPMC5154018

OpenAlexW2561943117

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.