ArticleThe Journal of nutritional biochemistry2017
Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice.
Article in The Journal of nutritional biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Oral iron-induced stunting is associated with increased Christensenella abundance in a piglet model for human infants.European journal of nutrition · 2026Article
- Docosahexaenoic Acid Promotes Cd Excretion by Restoring the Abundance ofMolecules (Basel, Switzerland) · 2023Article
- Urine-based Detection of Congenital Portosystemic Shunt in C57BL/6 Mice.Function (Oxford, England) · 2023Article
- Threonine Facilitates Cd Excretion by Increasing the Abundance of GutMolecules (Basel, Switzerland) · 2022Article
- Enterobactin induces the chemokine, interleukin-8, from intestinal epithelia by chelating intracellular iron.Gut microbes · 2020Article
- Enterobactin, an iron chelating bacterial siderophore, arrests cancer cell proliferation.Biochemical pharmacology · 2019Article
- The bacterial siderophore enterobactin confers survival advantage toGut microbes · 2019Article
- Gut Microbiota and Iron: The Crucial Actors in Health and Disease.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Bacterial Siderophores Hijack Neutrophil Functions.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- "Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levels.Pflugers Archiv : European journal of physiology · 2017Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Mammalian siderophores are believed to play a critical role in maintaining iron homeostasis. However, the properties and functions of mammalian siderophores have not been fully clarified. In this study, we have employed Chrome Azurol S (CAS) assay which is a well-established method for bacterial siderophores study, to detect and quantify mammalian siderophores in urine samples. Our study demonstrates that siderophores in urine can be altered by diet, gut microbiota and inflammation. C57BL/6 mice, fed on plant-based chow diets which contain numerous phytochemicals, have more siderophores in the urine compared to those fed on purified diets. Urinary siderophores were up-regulated in iron overload conditions, but not altered by other tested nutrients status. Further, germ-free mice displayed 50% reduced urinary siderophores, in comparison to conventional mice, indicating microbiota biotransformation is critical in generating or stimulating host metabolism to create more siderophores. Altered urinary siderophores levels during inflammation suggest that host health conditions influence systemic siderophores level. This is the first report to measure urinary siderophores as a whole, describing how siderophores levels are modulated under different physiological conditions. We believe that our study opens up a new field in mammalian siderophores research and the technique we used in a novel manner has the potential to be applied to clinical purpose.
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