Evidence map›Paper›PMID 27943658›Full record

ArticleJournal of biophotonics2017

Objective identification of dental abnormalities with multispectral fluorescence imaging.

Surya Pratap Singh, Pauli Fält, Ishan Barman, Arto Koistinen, Ramachandra Rao Dasari, Arja M Kullaa

Abstract read
In one paragraph

Article in Journal of biophotonics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Surya Pratap SinghInstitute of Dentistry, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Pauli FältSIB Labs, University of Eastern Finland, Kuopio, Finland.
Ishan BarmanDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland, 21218, USA.
Arto KoistinenSIB Labs, University of Eastern Finland, Kuopio, Finland.
Ramachandra Rao DasariLaser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, MA, 02139, USA.
Arja M KullaaInstitute of Dentistry, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Funding

Wide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3M
NIBIB NIH HHS P41 EB015871
6 · The paper itself

Abstract

Sensitive methods that can enable early detection of dental diseases (caries and calculus) are desirable in clinical practice. Optical spectroscopic approaches have emerged as promising alternatives owing to their wealth of molecular information and lack of sample preparation requirements. In the present study, using multispectral fluorescence imaging, we have demonstrated that dental caries and calculus can be objectively identified on extracted tooth. Spectral differences among control, carious and calculus conditions were attributed to the porphyrin pigment content, which is a byproduct of bacterial metabolism. Spectral maps generated using different porphyrin bands offer important clues to the spread of bacterial infection. Statistically significant differences utilizing fluorescence intensity ratios were observed among three groups. In contrast to laser induced fluorescence, these methods can provide information about exact spread of the infection and may aid in long term dental monitoring. Successful adoption of this approach for routine clinical usage can assist dentists in implementing timely remedial measures.

Indexed as

Optical ImagingSpectrum AnalysisStomatognathic DiseasesbiophotonicsdentistryFluorescence spectroscopymultispectral imaging

Identifiers

PMID27943658
PMCPMC5468489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.