Evidence map›Paper›PMID 27943541›Full record

ArticleJournal of thrombosis and haemostasis : JTH2017

P-selectin can promote thrombus propagation independently of both von Willebrand factor and thrombospondin-1 in mice.

P Prakash, M K Nayak, A K Chauhan

Open access · bronzeAbstract read
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Platelets in Wound Healing: What Happens in Space?Frontiers in bioengineering and biotechnology · 2021
    Review
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

P PrakashDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-9501-0065
M K NayakDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
A K ChauhanDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
University of Iowa · US

Funding

Mechanisms of Fibronectin Extra Domain A in AtherosclerosisR01HL118246 · NHLBI · UNIVERSITY OF IOWA · PI CHAUHAN, ANIL KUMAR · 2013 to 2017
$1.9M
Fibronectin alternative splicing in thrombosis and inflammationR01HL118742 · NHLBI · UNIVERSITY OF IOWA · PI CHAUHAN, ANIL KUMAR · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL118246NHLBI NIH HHS R01 HL118742
6 · The paper itself

Abstract

Essentials The main receptor for platelet glycoprotein (GP) Ibα is von Willebrand factor (VWF). P-selectin and thrombospondin-1 (TSP1) have been suggested as counter receptors for GPIbα. In a laser injury model, P-selectin promotes thrombus propagation independently of VWF and TSP1. In a laser injury model, thrombus persists in interleukin-4 receptor α/GPIbα-transgenic mice. SUMMARY: Background P-selectin and thrombospondin-1 (TSP1) have been suggested as counter ligands that may mediate GPIbα-dependent thrombus growth independently of von Willebrand factor (VWF) in vitro. However, residual thrombus formation still persists in Vwf

Indexed as

AnimalsAnticoagulantsBlood PlateletsChloridesDisease Models, AnimalFerric CompoundsImmunoglobulin GLasersMiceMice, Inbred C57BLMice, KnockoutPlatelet ActivationPlatelet AdhesivenessProtein BindingP-SelectinThrombosisAnticoagulantsChloridesferric chlorideFerric CompoundsImmunoglobulin GP-SelectinThrombospondin 1von Willebrand Factorarterial thrombosisplateletsP-selectinthrombospondin-1von Willebrand factor

Identifiers

PMID27943541
PMCPMC5305620
OpenAlexW2560175273

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.