ArticleExperimental dermatology2017
Aberrant connective tissue differentiation towards cartilage and bone underlies human keloids in African Americans.
Article in Experimental dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Medico-legal assessment of physical abuses in asylum cases: a multidisciplinary role for multiform issues.Forensic science, medicine, and pathology · 2026Article
- Integrative analysis identifies FERMT3 as a key regulator of metabolic reprogramming in keloid scarring and metabolic syndrome.Functional & integrative genomics · 2025Article
- Angiopoietin-like protein 2 mediates vasculopathy-driven fibrogenesis in a mouse model of systemic sclerosis.The Journal of clinical investigation · 2025Article
- Comprehensive analysis of keloid super-enhancer networks reveals FOXP1-mediated anti-senescence mechanisms in fibrosis.Cellular & molecular biology letters · 2025Article
- Identification of potential therapeutic target SPP1 and related RNA regulatory pathway in keloid based on bioinformatics analysis.Annals of medicine · 2024Article
- Exclusive expression of KANK4 promotes myofibroblast mobility in keloid tissues.Scientific reports · 2024Article
- Defining a Unique Gene Expression Profile in Mature and Developing Keloids.JID innovations : skin science from molecules to population health · 2023Article
- [Keloid nomogram prediction model based on weighted gene co-expression network analysis and machine learning].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Article
- Bioinformatics analysis and identification of dysregulated POSTN in the pathogenesis of keloid.International wound journal · 2023Article
- Multi-omics integrative analysis reveals the role of tumor necrosis factor superfamily member 4 in keloidal scarring.American journal of translational research · 2023Article
- Adipose-Derived Stromal/Stem Cell Response to Tumors and Wounds: Evaluation of Patient Age.Stem cells and development · 2022Review
- Identification and characterization of four immune-related signatures in keloid.Frontiers in immunology · 2022Article
- Identification and Validation of Novel Diagnostic Biomarkers for Keloid Based on GEO Database.International journal of general medicine · 2022Article
- The Downregulated Lipo-Related Gene Expression Pattern in Keloid Indicates Fat Graft Is a Potential Clinical Option for Keloid.Frontiers in medicine · 2022Article
- Identifying miRNAs Associated with the Progression of Keloid through mRNA-miRNA Network Analysis and Validating the Targets of miR-29a-3p in Keloid Fibroblasts.BioMed research international · 2022Article
- Bioinformatic Analysis of Key Genes and Pathways Related to Keloids.BioMed research international · 2021Article
- Genomics of Human Fibrotic Diseases: Disordered Wound Healing Response.International journal of molecular sciences · 2020Review
- Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds.Nature communications · 2020Article
- The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars.Journal of immunology research · 2020Article
- RNA Sequencing Keloid Transcriptome Associates Keloids With Th2, Th1, Th17/Th22, and JAK3-Skewing.Frontiers in immunology · 2020Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Keloids are benign fibroproliferative tumors more frequently found among African Americans. Until now, keloid etiopathogenesis is not fully understood. To characterize keloids in African Americans, we performed transcriptional profiling of biopsies from large chronic keloids, adjacent non-lesional (NL) skin (n=3) and a newly formed keloid lesion using Affymetrix HGU133 2.0 plus arrays. Quantitative RT-PCR (qRT-PCR) and immunohistochemistry (IHC) staining were performed to confirm increased expression of relevant genes. We identified 1202 upregulated and 961 downregulated differentially expressed genes (DEGs) between keloid and NL skin; 1819 up- and 1867 downregulated DEGs between newly formed keloid and NL skin; and 492 up- and 775 downregulated DEGs between chronic and newly formed keloid (fold change >2, false discovery rate <0.05). Many of the top upregulated DEGs between chronic keloid and NL skin and between newly formed keloid and NL skin are involved in bone/cartilage formation including Fibrillin 2 (FBN2), Collagen type X alpha 1, Asporin (ASPN), Cadherin 11 (CDH11), Bone morphogenic protein 1 (BMP1), Secreted phosphoprotein 1 and Runt-related transcription factor 2 (RUNX2). qRT-PCR confirmed significant (P<.05) upregulation of BMP1, RUNX2, CDH11 and FBN2 in chronic keloid compared to NL skin. IHC staining showed increased protein expression of ASPN, CDH11, BMP1 and RUNX2 on chronic and newly formed keloid compared to NL skin. Our study shows that large keloids in African Americans represent a dysplasia of cutaneous connective tissue towards immature cartilage or bone differentiation. The phenotype is potentially regulated by overexpression of RUNX2. This knowledge may give insights to guide the development of better treatment for the disease in the future.
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