ArticleTransfusion2017
A large national study of ferritin testing in Canadian blood donors.
Article in Transfusion, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Diagnostic accuracy of reticulocyte haemoglobin content in detecting iron deficiency without anaemia in blood donors: A systematic review and meta-analysis.Vox sanguinis · 2026Pooled it
- What is the impact of whole-blood donation frequency on donor health? A systematic review.Vox sanguinis · 2026Pooled it
- Cost-effectiveness of alternative minimum recall intervals between whole blood donations.PloS one · 2022Trial
- Longer-term efficiency and safety of increasing the frequency of whole blood donation (INTERVAL): extension study of a randomised trial of 20 757 blood donors.The Lancet. Haematology · 2019Trial
- Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors.Lancet (London, England) · 2017Trial
- The operational implications of donor behaviors following enrollment in STRIDE (Strategies to Reduce Iron Deficiency in blood donors).Transfusion · 2017Trial
- Assessment of implementation of ferritin testing on donor return.Transfusion · 2026Article
- Limitations of the Male/Female Binary for Studying the Influences of Sex- and Gender-Related Factors on Health.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Evaluating utility of routine ferritin testing in blood donors: A hospital-based blood donor centre experience.Transfusion medicine (Oxford, England) · 2024Article
- Article
- Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis.Open medicine (Warsaw, Poland) · 2024Article
- A reference interval study of ferritin and transferrin levels in donors from two blood centers.Experimental and therapeutic medicine · 2023Article
- REASONS FOR DEFERRAL IN DEFERRED VOLUNTARY BLOOD DONORS IN EASTERN CROATIA.Acta clinica Croatica · 2023Article
- Using Capillary Whole Blood to Quantitatively Measure Ferritin: A Validation Trial of a Point-of-Care System.Nutrients · 2023Article
- Eligibility Considerations for Female Whole Blood Donors: Hemoglobin Levels and Iron Status in a Nationally Representative Population.Transfusion medicine reviews · 2023Article
- Prevalence of Iron Deficiency, Anemia, and Associated Factors in a Blood Donor Population in Brazzaville, Congo.Anemia · 2023Article
- Transcending the Male-Female Binary in Biomedical Research: Constellations, Heterogeneity, and Mechanism When Considering Sex and Gender.International journal of environmental research and public health · 2022Article
- Sex, Gender and Health: Mapping the Landscape of Research and Policy.International journal of environmental research and public health · 2022Article
- Article
- Oral iron and blood donation: cui bono?Blood transfusion = Trasfusione del sangue · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe assessed risk groups for iron deficiency and the feasibility and efficacy of ferritin testing in a large blood center. STUDY DESIGN AND
methodsDonors were informed of possible testing in the predonation pamphlet. Plasma ferritin was measured on retention samples (n = 12,595) from representative clinics. Low-ferritin donors (<25 µg/L) were sent a letter and information sheet and not called for 6 months. Ferritin testing was repeated on 25% of donors; donor return rate and frequency were monitored.
resultsLow-ferritin donors represented 2.9% of first-time and reactivated (no donation in past 12 months) male donors, 32.2% of first-time and reactivated female donors, 41.6% of repeat male donors, and 65.1% of repeat female donors. A mean of 11.7 months after index donation, the return rate was 76% for normal and 58% for low-ferritin donors; returning low-ferritin donors had made approximately one fewer donation. Ferritin increased by 16.3 and 12.1 µg/L in male and female low-ferritin donors and decreased by 17 µg/L in male and female normal-ferritin donors.
conclusionThe minimum hemoglobin level will be increased to 130 g/L for male donors and the minimum interdonation interval changed to 84 days (four donations yearly) for female donors based on iron deficiency risk groups. Large-scale ferritin testing was feasible. Donors informed of low-ferritin results had a lower return rate, donated less often, and had an increase in ferritin on return, approximately 1 year after initial testing, compared to donors with normal ferritin results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.