ReviewJournal of experimental orthopaedics2016
Quantitative Computed Tomography (QCT) derived Bone Mineral Density (BMD) in finite element studies: a review of the literature.
Review in Journal of experimental orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Opportunistic CT-based osteoporosis screening of the hip: a systematic review of diagnostic accuracy.Archives of orthopaedic and trauma surgery · 2025Pooled it
- Change in CT-measured acetabular bone density following total hip arthroplasty: a systematic review and meta-analysis.Acta orthopaedica · 2023Pooled it
- A randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy of the synbiotic medical food, SBD111, for the clinical dietary management of bone loss in menopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Trial
- Phantomless calibration of glenoid trabecular bone density: improved accuracy using age-stratified reference tissue densities.JBMR plus · 2026Article
- Patient-Specific Adaptation of a Mechano-Regulatory Bone-Healing Model Using Longitudinal Loading Data.Annals of biomedical engineering · 2026Article
- Single and combined effects of parenteral vitamins DPoultry science · 2026Article
- Predictive efficacy of phantom-less calibration of computed tomography for cage subsidence after anterior cervical discectomy and fusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Internal Density Calibration in the Proximal Humerus to Estimate Bone Stiffness for Stemless Shoulder Arthroplasty.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Evidence-informed methodological approaches for coupled neuromusculoskeletal-finite element analysis workflows in orthopaedic biomechanics.Frontiers in bioengineering and biotechnology · 2026Article
- Article
- Adjacent Vertebral BMD Decline After Lateral Lumbar Interbody Fusion.Orthopaedic surgery · 2025Article
- Accuracy and Robustness of Bone Volume Fraction Assessment by Photon-Counting, Dual-Energy, and Quantitative CT using Micro-CT as Standard of Reference.Annals of biomedical engineering · 2025Article
- Predicting the Risk for Pathological Fracture in Bone Metastases.Current oncology (Toronto, Ont.) · 2025Review
- Tuning and validation of a virtual mechanical testing pipeline for condylar stress fracture risk assessment in Thoroughbred racehorses.Royal Society open science · 2025Article
- Article
- A Novel Approach by Integrating CT-Based Imaging Data and Machine Learning to Predict Patient-Specific Young's Modulus Values.Advances in orthopedics · 2025Article
- Predicting the effect of individual weight-bearing on tibial load and fracture healing after tibial plateau fractures-introduction of a biomechanical simulation model.Frontiers in bioengineering and biotechnology · 2025Article
- Biomechanical perspectives on image-based hip fracture risk assessment: advances and challenges.Frontiers in endocrinology · 2025Review
- Review
- Phantomless calibration of CT scans for hip fracture risk prediction in silico: Comparison with phantom-based calibration.PloS one · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFinite element modeling of human bone provides a powerful tool to evaluate a wide variety of outcomes in a highly repeatable and parametric manner. These models are most often derived from computed tomography data, with mechanical properties related to bone mineral density (BMD) from the x-ray energy attenuation provided from this data. To increase accuracy, many researchers report the use of quantitative computed tomography (QCT), in which a calibration phantom is used during image acquisition to improve the estimation of BMD. Since model accuracy is dependent on the methods used in the calculation of BMD and density-mechanical property relationships, it is important to use relationships developed for the same anatomical location and using the same scanner settings, as these may impact model accuracy. The purpose of this literature review is to report the relationships used in the conversion of QCT equivalent density measures to ash, apparent, and/or tissue densities in recent finite element (FE) studies used in common density-modulus relationships. For studies reporting experimental validation, the validation metrics and results are presented.
resultsOf the studies reviewed, 29% reported the use of a dipotassium phosphate (K
conclusionsThis review assessed the current state of QCT-based FE modeling with use of clinical scanners. It was found that previously developed densitometric relationships vary by anatomical location, scanner type and settings. Reporting of all parameters used when referring to previously developed relationships, or in the development of new relationships, may increase the accuracy and repeatability of future FE models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.