Evidence map›Paper›PMID 27943221›Full record

ArticleClinical pharmacokinetics2017

A Population Pharmacokinetic Model for

Isabelle H S Kuan, Stephen B Duffull, Tracey L Putt, John B W Schollum, Robert J Walker, Daniel F B Wright

Abstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Clinical pharmacokinetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isabelle H S KuanSchool of Pharmacy, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
Stephen B DuffullSchool of Pharmacy, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
Tracey L PuttDepartment of Medicine, University of Otago, Dunedin, New Zealand.
John B W SchollumDepartment of Medicine, University of Otago, Dunedin, New Zealand.
Robert J WalkerDepartment of Medicine, University of Otago, Dunedin, New Zealand.
Daniel F B WrightSchool of Pharmacy, University of Otago, PO Box 56, Dunedin, 9054, New Zealand. dan.wright@otago.ac.nz.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesPATIENTS AND

methodsData from 40 individuals who received ~7.4 MBq of

resultsA two-compartment pharmacokinetic model with first-order elimination best fit the data. Compared with the model predictions, creatinine CL from 24 h urine data was unbiased. The commonly used 'slope-intercept' method for estimating isotopic GFR was positively biased compared with the model (MPE 15.5 mL/min/1.73 m

conclusionsThe biased GFR estimates were most obvious in patients with relatively normal renal function. This may lead to inaccurate dosing in patients who are receiving drugs with a narrow therapeutic range where dosing is adjusted according to GFR estimates (e.g. carboplatin). STUDY REGISTRATION: The study is registered with the Australian New Zealand Clinical Trials Registry (ANZCTR), number: ACTRN 12611000035921.

Indexed as

Models, BiologicalAdultAgedAged, 80 and overChromium RadioisotopesEdetic AcidFemaleGlomerular Filtration RateHumansKidneyKidney DiseasesMaleYoung AdultChromium RadioisotopesEdetic Acid

Identifiers

PMID27943221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.