SynthesisSports medicine (Auckland, N.Z.)2017
Association Between Exercise-Induced Hyperthermia and Intestinal Permeability: A Systematic Review.
Synthesis in Sports medicine (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Pooled it
- The Effects of Exercise on Indirect Markers of Gut Damage and Permeability: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Effects of exercise in cool versus hot conditions on pathways of gut permeability, systemic inflammation, and iron homeostasis in female athletes.Physiological reports · 2026Trial
- Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia after Running in the Heat.Medicine and science in sports and exercise · 2025Trial
- Effects of oral cystine and glutamine on exercise-induced changes in gastrointestinal permeability and damage markers in young men.European journal of nutrition · 2022Trial
- Trial
- Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults.Gastroenterology · 2021Trial
- Four weeks of probiotic supplementation reduces GI symptoms during a marathon race.European journal of applied physiology · 2019Trial
- The impact of exertional-heat stress on gastrointestinal integrity, gastrointestinal symptoms, systemic endotoxin and cytokine profile.European journal of applied physiology · 2018Trial
- Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner.European journal of applied physiology · 2017Trial
- Intestinal fatty acid-binding protein and gut permeability responses to exercise.European journal of applied physiology · 2017Trial
- Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes.Nutrients · 2017Trial
- Differential Intestinal Epithelial Injury Following Passive and Exertional Hyperthermia.Sports medicine - open · 2026Article
- Nutrition for Tactical Athletes: Insights, Applications and Research Gaps.Sports medicine (Auckland, N.Z.) · 2026Review
- Ad libitum drinking does not mitigate acute kidney injury risk nor elevations in markers of oxidative stress and inflammation during simulated occupational heat stress.American journal of physiology. Renal physiology · 2026Article
- Exercise-induced intestinal barrier dysfunction: a potential contributor to athlete mental health.BMJ open sport & exercise medicine · 2026Article
- Effect of foot immersion and neck cooling on renal, intestinal, immune and inflammatory markers in older adults exposed to extreme heat.Experimental physiology · 2025Article
- Biomarkers of organ stress and injury following the Boston Marathon.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Prolonged Humid Heat Triggers Systemic Inflammation and Stress Signaling: Fluid Intake Modulates NF-κB, p38, JNK2, and STAT3α Pathways.International journal of molecular sciences · 2025Article
- Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProlonged and strenuous physical exercise increases intestinal permeability, allowing luminal endotoxins to translocate through the intestinal barrier and reach the bloodstream. When recognized by the immune system, these endotoxins trigger a systemic inflammatory response that may affect physical performance and, in severe cases, induce heat stroke. However, it remains to be elucidated whether there is a relationship between the magnitude of exercise-induced hyperthermia and changes in intestinal permeability.
objectiveIn this systematic review, we evaluated whether an exercise-induced increase in core body temperature (T
methodsThe present systematic review screened the MEDLINE/PubMed and Web of Science databases in September 2016, without any date restrictions. Sixteen studies that were performed in healthy participants, presented original data, and measured both the exercise-induced changes in T
resultsExercise increased both T
conclusionThe magnitude of exercise-induced hyperthermia is directly associated with the increase in intestinal permeability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.