Evidence map›Paper›PMID 27942960›Full record

ArticleJournal of muscle research and cell motility2016

Comparison of elementary steps of the cross-bridge cycle in rat papillary muscle fibers expressing α- and β-myosin heavy chain with sinusoidal analysis.

Masataka Kawai, Tarek S Karam, John Jeshurun Michael, Li Wang, Murali Chandra

Abstract read
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In one paragraph

Article in Journal of muscle research and cell motility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Masataka KawaiDepartments of Anatomy and Cell Biology, and Internal Medicine, College of Medicine, University of Iowa, Iowa City, IA, 52242, USA. masataka-kawai@uiowa.edu.
Tarek S KaramDepartments of Anatomy and Cell Biology, and Internal Medicine, College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
John Jeshurun MichaelDepartment of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164-7620, USA.
Li WangDepartments of Anatomy and Cell Biology, and Internal Medicine, College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Murali ChandraDepartment of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164-7620, USA.
University of Iowa · USWashington State University · USSoochow University · CN

Funding

Mechanistic Understanding of Troponin T Role in Cardiac Thin Filament ActivationR01HL075643 · NHLBI · WASHINGTON STATE UNIVERSITY · PI CHANDRA, MURALI · 2004 to 2012
$2.7M
NHLBI NIH HHS R01 HL075643
6 · The paper itself

Abstract

In mammalian ventricles, two myosin heavy chain (MHC) isoforms have been identified. Small animals express α-MHC, whereas large animals express β-MHC, which contribute to a large difference in the heart rate. Sprague-Dawley rats possessing ~99% α-MHC were treated with propylthiouracil to result in 100% β-MHC. Papillary muscles were skinned, dissected into small fibers, and used for experiments. To understand the functional difference between α-MHC and β-MHC, skinned-fibers were activated under the intracellular ionic conditions: 5 mM MgATP, 1 mM Mg

Indexed as

Adenosine DiphosphateAdenosine TriphosphateAnimalsCalciumMaleMuscle Fibers, SkeletalMyosin Heavy ChainsPapillary MusclesPhosphatesRatsRats, Sprague-DawleyVentricular MyosinsAdenosine DiphosphateAdenosine TriphosphateCalciumMyosin Heavy ChainsPhosphatesVentricular MyosinsCross-bridge kineticsEffect of ATPEffect of CaEffect of PiElementary steps of cross-bridge cycleMyosin heavy chain isoformspCa-tensionRigor stiffness

Identifiers

PMID27942960
OpenAlexW2560304424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.