ArticlePlant molecular biology2017
ABI5-binding proteins (AFPs) alter transcription of ABA-induced genes via a variety of interactions with chromatin modifiers.
Article in Plant molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Dry side of the core: a meta-analysis addressing the original nature of the ABA signalosome at the onset of seed imbibition.Frontiers in plant science · 2023Pooled it
- A phosphatidic acid-based retrograde signaling pathway responsive to abiotic stress in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Gene network analysis predicts the primary regulators of ABA-dependent transcriptional activation and repression in Populus roots.PLoS genetics · 2026Article
- AHG1-AFP interaction as a regulatory node in the ABA response during seed germination.The Plant journal : for cell and molecular biology · 2026Article
- ABI5-binding proteins are substrates of key components in the ABA core signaling pathway affecting seeds.Plant physiology · 2026Article
- Beyond light signaling: the broad regulatory spectrum of AFPs in plant growth and development.Frontiers in plant science · 2026Review
- Identification of CsAFP3-like as a novel gene regulating determinate growth of lateral branch in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Root remodeling mechanisms and salt tolerance trade-offs: The roles of HKT1, TMAC2, and TIP2;2 in Arabidopsis.PLoS genetics · 2025Article
- Genome-wide associations of sweetpotato metabolites enhance genomic prediction and identify genes in metabolic and regulatory pathways.Scientific reports · 2025Article
- Nitrate attenuates abscisic acid signaling via NIN-LIKE PROTEIN8 in Arabidopsis seed germination.The Plant cell · 2025Article
- DOG1 controls dormancy independently of ABA core signaling kinases regulation by preventing AFP dephosphorylation through AHG1.Science advances · 2025Article
- The dynamic regulatory network of stamens and pistils in papaya.BMC plant biology · 2025Article
- A commitment for life: Decades of unraveling the molecular mechanisms behind seed dormancy and germination.The Plant cell · 2024Review
- Distinct guard cell-specific remodeling of chromatin accessibility during abscisic acid- and COProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Distinct guard cell specific remodeling of chromatin accessibility during abscisic acid and CObioRxiv : the preprint server for biology · 2023Article
- Auxin contributes to jasmonate-mediated regulation of abscisic acid signaling during seed germination in Arabidopsis.The Plant cell · 2023Article
- ABI5 binding protein2 inhibits ABA responses during germination without ABA-INSENSITIVE5 degradation.Plant physiology · 2022Article
- Overexpression of ABI5 Binding Proteins Suppresses Inhibition of Germination Due to Overaccumulation of DELLA Proteins.International journal of molecular sciences · 2022Article
- TOPLESS promotes plant immunity by repressing auxin signaling and is targeted by the fungal effector Naked1.Plant communications · 2022Article
- Landscape of biomolecular condensates in heat stress responses.Frontiers in plant science · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageOverexpression of ABI5/ABF binding proteins (AFPs) results in extreme ABA resistance of seeds via multiple mechanisms repressing ABA response, including interactions with histone deacetylases and the co-repressor TOPLESS. Several ABI5/ABF binding proteins (AFPs) inhibit ABA response, resulting in extreme ABA resistance in transgenic Arabidopsis overexpression lines, but their mechanism of action has remained obscure. By analogy to the related Novel Interactor of JAZ (NINJA) protein, it was suggested that the AFPs interact with the co-repressor TOPLESS to inhibit ABA-regulated gene expression. This study shows that the AFPs that inhibit ABA response have intrinsic repressor activity in a heterologous system, which does not depend on the domain involved in the interaction with TOPLESS. This domain is also not essential for repressing ABA response in transgenic plants, but does contribute to stronger ABA resistance. Additional interactions between some AFPs and histone deacetylase subunits were observed in yeast two-hybrid and bimolecular fluorescence assays, consistent with a more direct mechanism of AFP-mediated repression of gene expression. Chemical inhibition of histone deacetylase activity by trichostatin A suppressed AFP effects on a small fraction of the ABI5-regulated genes tested. Collectively, these results suggest that the AFPs participate in multiple mechanisms modulating ABA response, including both TOPLESS-dependent and -independent chromatin modification.
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