ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2017
Modification of PMMA vertebroplasty cement for reduced stiffness by addition of normal saline: a material properties evaluation.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Bioactive mineralized small intestinal submucosa acellular matrix/PMMA bone cement for vertebral bone regeneration.Regenerative biomaterials · 2023Article
- Precision medicine strategies for spinal degenerative diseases: Injectable biomaterials with in situ repair and regeneration.Materials today. Bio · 2022Review
- The Impact of Contaminating Poly (Methyl Methacrylate) (PMMA) Bone Cements on Their Compressive Strength.Materials (Basel, Switzerland) · 2021Article
- Release characteristics of enoxaparin sodium-loaded polymethylmethacrylate bone cement.Journal of orthopaedic surgery and research · 2021Article
- Effect of Physiological Saline Solution Contamination on Selected Mechanical Properties of Seasoned Acrylic Bone Cements of Medium and High Viscosity.Materials (Basel, Switzerland) · 2020Article
- Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties.Polymers · 2020Article
- PMMA-FeTheranostics · 2019Article
- Is vertebral body stenting in combination with CaP cement superior to kyphoplasty?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018Article
- Timing of PMMA cement application for pedicle screw augmentation affects screw anchorage.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVertebral augmentation is an established treatment for patients with pathological vertebral compression fractures. These procedures typically employ a PMMA-based bone cement, which possesses a high compressive stiffness. Because of the increased risk of subsequent fractures after vertebral augmentations, there is a desire for reducing this stiffness. The goal of our study was to examine the influence of adding isotonic saline on the biomechanical properties of PMMA vertebroplasty cement.
methodsA PMMA-based vertebroplasty cement was prepared according to the manufacturer's recommendations after which isotonic saline was mixed into the cement at 10, 20, and 30% (volume:volume). Testing bodies were cast, and compression and bending tests were performed. Fracture surfaces were studied using SEM. Measurements of injectability, setting temperature, and radioopacity were also performed.
resultsThe addition of saline solution (of up to vol-30%) led to a pronounced reduction in the compression modulus of the cement from 3409 ± 312 to 1131 ± 127 MPa. In parallel, maximal compression strength was reduced from 86 ± 4 to 33 ± 3 MPa and bending strength from 40 ± 4 to 24 ± 3 MPa. The differences regarding injectability, setting temperature, and radioopacity were small and probably of no clinical relevance.
conclusionsThe compressive stiffness of PMMA-based vertebroplasty cement can be reduced to almost a third by the addition of saline. The probable explanation is an increase in microporosity. Future simulator experiments will show whether the achieved reduction in stiffness is large enough to reduce the rate of subsequent vertebral fractures.
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