ArticlePediatric radiology2017
Percutaneous guided biopsy for diagnosing suspected primary malignant bone tumors in pediatric patients: a safe, accurate, and cost-saving procedure.
Article in Pediatric radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- CT-guided bone biopsies with non-diagnostic results in pediatric patients-a multi-institutional 10-year retrospective review.European radiology · 2026Article
- Results of percutaneous needle culture sampling and synchronous irrigation with Dakins' solution in Wagner Grade 3 diabetic foot osteomyelitis.Scientific reports · 2026Article
- Diagnostic value and related factors of ultrasound-guided percutaneous needle biopsy in bone lesions suspicious for tumor.BMC musculoskeletal disorders · 2026Article
- Multidisciplinary Tumor Board Evaluation of Pediatric Patients with Adrenocortical Tumors Across Seven International Centers.Cancers · 2025Article
- Article
- Diagnostic yield and concordance of image-guided biopsy in musculoskeletal lesions.Skeletal radiology · 2024Article
- In situ guidance for MRI interventions using projected feedback.International journal of computer assisted radiology and surgery · 2023Article
- Pediatric and Young Adult Image-Guided Percutaneous Bone Biopsy-A New Standard of Care?Annals of surgical oncology · 2023Article
- Percutaneous Core Needle Biopsy Can Efficiently and Safely Diagnose Most Primary Bone Tumors.Diagnostics (Basel, Switzerland) · 2021Article
- Paediatric bone lesions: diagnostic accuracy of imaging correlation and CT-guided needle biopsy for differentiating benign from malignant lesions.The British journal of radiology · 2021Article
- Diagnostic accuracies of intraoperative frozen section and permanent section examinations for histological grades during open biopsy of bone tumors.International journal of clinical oncology · 2021Article
- A small-cohort study on tumor recurrence and surgery-related complications associated with proximal fibular tumors and the potential utility of biopsy.Journal of clinical and translational research · 2021Article
- Accuracy of histological grades from intraoperative frozen-section diagnoses of soft-tissue tumors.International journal of clinical oncology · 2020Article
- PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?Cancer imaging : the official publication of the International Cancer Imaging Society · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPercutaneous biopsy is the reference diagnostic procedure for adult musculoskeletal tumors. Its place in pediatrics is controversial and open biopsy remains recommended.
objectiveTo assess diagnostic performance and feasibility of percutaneous biopsy performed on children and young adults for suspected malignant bone tumors. MATERIALS AND
methodsWe conducted a 5-year retrospective study including patients ≤21 years who underwent a bone biopsy for a suspected malignant bone tumor. We assessed diagnostic yield (percentage of analyzable biopsies), accuracy (percentage of accurate diagnoses among all analyzable biopsies) and efficacy (percentage of accurate diagnoses among all biopsies), costs, anesthetic requirements and sample availability for biomedical research. Patients diagnosed with an open biopsy were used to compare diagnostic performances, anesthetic requirements and costs.
resultsWe included 90 percutaneous and 27 open biopsies in 117 patients. For percutaneous biopsy, diagnostic yield was 95.5% (95% confidence interval [CI] 88.8-98.7%), accuracy was 96.2% (95% CI 86.8-99.5%) and efficacy was 89.3% (95% CI 78.1-96.0%). There was no statistical difference with open biopsy (Fisher exact test, P > 0.05). Mean costs were reduced with percutaneous biopsy: €1,937 (standard deviation [SD] €2,408) versus €6,362 (SD €5,033; Mann-Whitney, P < 0.0001). Thirty-two of the 48 (67%) patients included in clinical trials and diagnosed with percutaneous biopsy had suitable samples for ancillary analyses.
conclusionPercutaneous biopsy is a valid alternative to open biopsy for diagnosing pediatric and young adult primary malignant bone tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.